Title:
HYDROGEN MOLECULE-CONTAINING PROPHYLACTIC OR THERAPEUTIC AGENT FOR OXIDATIVE STRESS DAMAGES IN INTERNAL EYE SURGERIES
Document Type and Number:
WIPO Patent Application WO/2017/126708
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a prophylactic or therapeutic agent for oxidative stress damages, which is intended to be administered during phacoemulsification and aspiration for cataract. The present invention is a hydrogen molecule-containing prophylactic or therapeutic agent for oxidative stress damages in internal eye surgeries.
Inventors:
TAKAHASHI HIROSHI (JP)
OSAWA IKURO (JP)
IGARASHI TSUTOMU (JP)
OSAWA IKURO (JP)
IGARASHI TSUTOMU (JP)
Application Number:
PCT/JP2017/002838
Publication Date:
July 27, 2017
Filing Date:
January 20, 2017
Export Citation:
Assignee:
TAKAHASHI HIROSHI (JP)
OSAWA IKURO (JP)
OSAWA IKURO (JP)
International Classes:
A61K33/00; A61K9/08; A61P27/02; A61P39/06
Foreign References:
| CN103006695A | 2013-04-03 |
Other References:
OHARAZAWA, H. ET AL.: "Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury", INVEST. OPHTHALMOL. VIS. SCI., vol. 51, no. 1, 2010, pages 487 - 492, XP055402919
TOPAZ, M. ET AL.: "Acoustic cavitation in phacoemulsification and the role of antioxidants", ULTRASOUND MED. BIOL., vol. 31, no. 8, 2005, pages 1123 - 1129, XP027605617
NEMET, A.Y. ET AL.: "Protective effect of free- radical scavengers on corneal endothelial damage in phacoemulsification", J. CATARACT REFRACT. SURG., vol. 33, no. 2, 2007, pages 310 - 315, XP005904115
NISHI, Y. ET AL.: "Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy", ACTA OPHTHALMOL., vol. 88, no. 8, 2010, pages e323 - E327, XP055402926
AUGUSTIN, A.J. ET AL.: "Oxidative tissue damage after phacoemulsification: influence of ophthalmic viscosurgical devices", J. CATARACT REFRACT. SURG., vol. 30, no. 2, 2004, pages 424 - 427, XP002365625
TOPAZ, M. ET AL.: "Acoustic cavitation in phacoemulsification and the role of antioxidants", ULTRASOUND MED. BIOL., vol. 31, no. 8, 2005, pages 1123 - 1129, XP027605617
NEMET, A.Y. ET AL.: "Protective effect of free- radical scavengers on corneal endothelial damage in phacoemulsification", J. CATARACT REFRACT. SURG., vol. 33, no. 2, 2007, pages 310 - 315, XP005904115
NISHI, Y. ET AL.: "Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy", ACTA OPHTHALMOL., vol. 88, no. 8, 2010, pages e323 - E327, XP055402926
AUGUSTIN, A.J. ET AL.: "Oxidative tissue damage after phacoemulsification: influence of ophthalmic viscosurgical devices", J. CATARACT REFRACT. SURG., vol. 30, no. 2, 2004, pages 424 - 427, XP002365625
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
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