Title:
HYDROLYSIS METHOD OF TERT-BUTYL ESTER USED IN GADOLINIUM CONTRAST AGENT
Document Type and Number:
WIPO Patent Application WO/2020/154891
Kind Code:
A1
Abstract:
The present invention provides a hydrolysis method of tert-butyl ester used in a gadolinium contrast agent. The hydrolysis method comprises the following steps: hydrolyzing the tert-butyl ester by using a catalyst; a preparation method for the catalyst comprising the following steps: performing a reaction on zirconium dioxide and titanium tetrachloride in the presence of sulfuric acid and water at 60-90°C until a solid is dissolved, adding silicon dioxide for reaction for 1-5 h, filtering a reaction product and collecting the solid, and roasting the solid after washing. According to the hydrolysis method, no acids or other substances difficult to remove are introduced into the hydrolysis method, so that the hydrolysis efficiency is high, and the purity of the obtained product is high.
Inventors:
ZHANG ZHIHUA (CN)
LIU YUNLONG (CN)
LIU YUNLONG (CN)
Application Number:
PCT/CN2019/073688
Publication Date:
August 06, 2020
Filing Date:
January 29, 2019
Export Citation:
Assignee:
HUBEI TIANSHU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C227/18; B01J21/06; B01J21/08; B01J27/10; B01J27/135; C07C229/16
Foreign References:
| CN109705104A | 2019-05-03 | |||
| CN103068790A | 2013-04-24 |
Other References:
See also references of EP 3835286A4
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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