Title:
HYDROPHILIC POLYMER DERIVATIVE HAVING SELF-IMMOLATIVE ACETAL LINKER AND COMPOSITE USING SAME
Document Type and Number:
WIPO Patent Application WO/2018/180914
Kind Code:
A1
Abstract:
Provided is a hydrophilic polymer derivative having a novel linker technology, wherein a hydrophilic polymer prodrug such as an amino group-containing drug can be formed to overcome limitations of conventional hydrophilic polymer prodrugs. The hydrophilic polymer derivative comprises a hydrophilic polymer part and an acetal part, and has a structure represented by formula (1) or formula (2).
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Inventors:
TSUBUSAKI TAKUMA (JP)
TAMAGAWA SHINYA (JP)
TAMAGAWA SHINYA (JP)
Application Number:
PCT/JP2018/011485
Publication Date:
October 04, 2018
Filing Date:
March 22, 2018
Export Citation:
Assignee:
NOF CORP (JP)
International Classes:
C08G65/329; A61K47/60
Domestic Patent References:
WO1999030727A1 | 1999-06-24 | |||
WO2000064483A2 | 2000-11-02 | |||
WO2005058367A2 | 2005-06-30 |
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JP2002508400A | 2002-03-19 | |||
JP2012500804A | 2012-01-12 | |||
JP2016194057A | 2016-11-17 | |||
JP2014208794A | 2014-11-06 | |||
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JOURNAL OF MEDICAL CHEMISTRY, vol. 42, no. 18, 1999, pages 3657 - 3667
WUTS, P. G M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
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TENG, N. N. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 7308 - 7312
KOZBOR, D. ET AL., IMMUNOLOGY TODAY, vol. 4, 1983, pages 72 - 79
OLSSON L. ET AL., METH. ENZYMOL., vol. 92, 1982, pages 3 - 16
MILSTEIN, C. ET AL., NATURE, vol. 305, 1983, pages 537 - 539
BIRD, R. E. ET AL., SCIENCE, vol. 242, 1988, pages 423 - 442
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SOT USA, vol. 85, 1988, pages 5879 - 5883
WARD, E. S. ET AL., NATURE, vol. 334, 1989, pages 544 - 554
TRAIL, P. A. ET AL., SCIENCE, vol. 261, 1993, pages 212 - 215
TRAIL, P. A. ET AL., CANCER RESEARCH, vol. 57, 1997, pages 100 - 105
FRANCISCO, J. A. ET AL., CANCER RES., vol. 60, 2000, pages 3225 - 3231
BOWEN, M. A. ET AL., J. IMMUNOL., vol. 151, 1993, pages 5896 - 5906
WAHL, A. F. ET AL., CANCER RES., vol. 62, no. 13, 2002, pages 3736 - 3742
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See also references of EP 3604384A4
JOURNAL OF MEDICAL CHEMISTRY, vol. 42, no. 18, 1999, pages 3657 - 3667
WUTS, P. G M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
ANGEW CHEM INTL. ED. ENGL., vol. 33, 1994, pages 183 - 186
MILLER, K. ET AL., J. IMMUNOL., vol. 170, 2003, pages 4854 - 4861
JANEWAY, C.TRAVERS, P.WALPORT, M.SHLOMCHIK, M.: "Immunobiology", 2001, GARLAND PUBLISHING
KOHLER, GMILSTEIN, C., NATURE, vol. 256, 1975, pages 495 - 497
KOZBOR, D. ET AL., IMMUNOL. TODAY, vol. 4, 1983, pages 72 - 79
COLE, S. P. C. ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, pages: 77 - 96
TENG, N. N. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 7308 - 7312
KOZBOR, D. ET AL., IMMUNOLOGY TODAY, vol. 4, 1983, pages 72 - 79
OLSSON L. ET AL., METH. ENZYMOL., vol. 92, 1982, pages 3 - 16
MILSTEIN, C. ET AL., NATURE, vol. 305, 1983, pages 537 - 539
BIRD, R. E. ET AL., SCIENCE, vol. 242, 1988, pages 423 - 442
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SOT USA, vol. 85, 1988, pages 5879 - 5883
WARD, E. S. ET AL., NATURE, vol. 334, 1989, pages 544 - 554
TRAIL, P. A. ET AL., SCIENCE, vol. 261, 1993, pages 212 - 215
TRAIL, P. A. ET AL., CANCER RESEARCH, vol. 57, 1997, pages 100 - 105
FRANCISCO, J. A. ET AL., CANCER RES., vol. 60, 2000, pages 3225 - 3231
BOWEN, M. A. ET AL., J. IMMUNOL., vol. 151, 1993, pages 5896 - 5906
WAHL, A. F. ET AL., CANCER RES., vol. 62, no. 13, 2002, pages 3736 - 3742
GLASOE, P. K.LONG, F. A., J. PHYS. CHEM., vol. 64, 1960, pages 188 - 190
FREEMAN, J. H., J. AM. CHEM. SOC., vol. 74, 1952, pages 6257 - 6260
See also references of EP 3604384A4
Attorney, Agent or Firm:
SHIN-EI PATENT FIRM, P.C. (JP)
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