HYDROPHOBIC NANOBIOPROBE

WIPO Patent Application WO/2020/098754

A1

Disclosed are a new nanobioprobe and the use thereof in targeted delivery of a bioactive molecule in cells. In particular, the application relates to a mixture solvent - an exposed hydrophobic QD-biomolecule (cS-bQD-BM, or 'SDot'). SDots exhibits extraordinary intracellular targeting performance with a nucleus as a model target, including near-perfect specificity, excellent efficiency and reproducibility, high throughput capability, minimal toxicity, easy manipulation, and outstanding optical properties and colloidal stability.

JP4974091	A DNA chip for predicting the onset of late adverse reactions in the urinary system after radiotherapy, and a method for predicting the onset of late adverse reactions in the urinary system after radiotherapy using the DNA chip.
JP2005536211	Oligonucleotide Tagging for Gene Analysis Nucleoside Triphosphate (OTNTP)
WO/2004/053151	EVOLVED CLOSTRIDIAL TOXINS WITH ALTERED PROTEASE SPECIFICITY

RUAN GANG (CN)
WANG JUN (CN)
XIE JINBING (CN)
MEI LING (CN)

PCT/CN2019/118571

May 22, 2020

November 14, 2019

Click for automatic bibliography generation  

UNIV NANJING (CN)

C12Q1/68; C12N15/11; G01N33/50

CN106318372A	2017-01-11
CN108610428A	2018-10-02
CN102786931A	2012-11-21
CN103748142A	2014-04-23

SMITH ANDREW ET AL.: "A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots", PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 8, 31 July 2016 (2016-07-31), pages 3895 - 3903, XP055708037
GANG: "Imaging and Tracking of Tat Peptide-Conjugated Quantum Dots in Living Cells: New Insights into Nanoparticle Uptake, Intracellular Transpo- rt, and Vesicle Shedding", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 47, 6 November 2007 (2007-11-06), pages 14759 - 14766, XP055708023
JUN: "Intracellular targeted delivery of quantum dots with extraordina- ry performance enabled by a novel nanomaterial design", NANOSCALE, vol. 11, no. 2, 13 December 2018 (2018-12-13) - 2019, pages 552 - 567, XP055708029

XU & PARTNERS, LLC. (CN)

View/Download PDF      PDF Help

Previous Patent: Improvements of Affine Prediction Mode

Next Patent: SMART HOME CONTROL METHOD, SMART HOME DEVICE, AND STORAGE MEDIUM