Title:
HYDROQUINONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION IN TUMOUR RESISTANCE OR IMMUNOMODULATION
Document Type and Number:
WIPO Patent Application WO/2017/125093
Kind Code:
A1
Abstract:
Disclosed are a hydroquinone compound, a preparation method therefor, and an application in tumour resistance or immunomodulation. The structural formula of the hydroquinone compound is as shown in formula I, wherein: X is C=O or CH2; Y is NH, O or absent; R is selected from any one of the following groups: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, and a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; a substituted or unsubstituted aryl group or heteroaryl group at least containing four carbon atoms. The compound slowly releases 2-tert-butyl-4-methoxyphenol in the body, overcomes the shortcoming that the half-life of 2-tert-butyl-4-methoxyphenol directly administered in the body is short (T1/2 = 0.5-1h), and maintains a stable 2-tert-butyl-4-methoxyphenol plasma concentration (T1/2 = 12-24h). The compound protects the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, prevents oxidation in the environment, and increases the environmental stability of a drug.
Inventors:
ZHANG XUEMIN (CN)
HE XINHUA (CN)
ZHOU TAO (CN)
LIU ZHENGGANG (CN)
LI TAO (CN)
HE XINHUA (CN)
ZHOU TAO (CN)
LIU ZHENGGANG (CN)
LI TAO (CN)
Application Number:
PCT/CN2017/074386
Publication Date:
July 27, 2017
Filing Date:
February 22, 2017
Export Citation:
Assignee:
BIOMEDICAL ANALYSIS CENTER ACAD OF MILITARY MEDICAL SCIENCES (CN)
INST OF PHARMACOLOGY AND TOXICOLOGY ACAD OF MILITARY MEDICAL SCIENCES (CN)
INST OF PHARMACOLOGY AND TOXICOLOGY ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07C271/44; A61K31/222; A61K31/23; A61K31/325; A61P35/00; C07C69/16; C07C69/28; C07C69/78; C07C271/56; C07D265/30
Foreign References:
CN1192148A | 1998-09-02 | |||
JPH09278741A | 1997-10-28 |
Other References:
SHEALY, Y.F. ET AL.: "Inhibition of Papilloma Formation by Analogues of 7, 8-Dihydroretinoic Acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 10, 8 May 2003 (2003-05-08), pages 1931 - 1939, XP055058512
MOSNACEK, J. ET AL.: "New Combined Phenol/Hindered Amine Photo-and Thermal-Stabilizers Based on Toluene-2, 4-Diisocyanate", POLYMER DEGRADATION AND STABILITY, vol. 80, no. 1, 31 January 2003 (2003-01-31), pages 113 - 126, XP004410433
MOSNACEK, J. ET AL.: "New Combined Phenol/Hindered Amine Photo-and Thermal-Stabilizers Based on Toluene-2, 4-Diisocyanate", POLYMER DEGRADATION AND STABILITY, vol. 80, no. 1, 31 January 2003 (2003-01-31), pages 113 - 126, XP004410433
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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