HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT

Title:

HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2006/016399

Kind Code:

A1

Abstract:

A compound which inhibits the production of IL-6 and/or TNF&agr by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNF&agr production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

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Inventors:

NAKATOGAWA KIYOSHI (JP)
TAKAGI MASAMICHI (JP)
AKASHIMA MAKOTO (JP)

Application Number:

PCT/JP2004/011473

Publication Date:

February 16, 2006

Filing Date:

August 10, 2004

Export Citation:

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Assignee:

SHIZUOKA COFFEIN CO LTD (JP)
NAKATOGAWA KIYOSHI (JP)
TAKAGI MASAMICHI (JP)
AKASHIMA MAKOTO (JP)

International Classes:

A61K31/421; A61K31/426; A61P1/00; A61P19/00; A61P19/10; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P43/00; C07D263/32; C07D277/22; (IPC1-7): C07D263/32; A61K31/421; A61K31/426; A61P1/00; A61P19/00; A61P19/10; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P43/00; C07D277/22

Foreign References:

JPH0517459A	1993-01-26
US20010056189A1	2001-12-27
US3538107A	1970-11-03
US3578671A	1971-05-11
JP2004250401A	2004-09-09

Other References:

DAI Y. ET AL.: "A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring system as connection units", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 21, 2003, pages 3817 - 3820, XP002904193
See also references of EP 1787986A4

Attorney, Agent or Firm:

Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)

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