Title:
HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2001/021583
Kind Code:
A1
Abstract:
Hydroxamic acid derivatives represented by general formula (I), nontoxic salts thereof or prodrugs of the same (wherein each symbol is as defined in the description). Because of inhibiting the production of IL-6, the compounds of the general formula (I) are useful as preventives and/or remedies for various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, kidney cell cancer, Kaposi's sarcoma, rheumatoid arthritis, hypergammaglobulinemia, Caslteman's disease, artial myxoma, diabetes, autoimmune diseases, hepatitis, colon inflammation, graft-versus-host disease, inflammation and endometriosis.
Inventors:
KONNO MITOSHI (JP)
SAKAKI KATSUHITO (JP)
NAKA MASAO (JP)
KONISHI MIKIO (JP)
KISHIMOTO TADAMITSU (JP)
SAKAKI KATSUHITO (JP)
NAKA MASAO (JP)
KONISHI MIKIO (JP)
KISHIMOTO TADAMITSU (JP)
Application Number:
PCT/JP2000/006506
Publication Date:
March 29, 2001
Filing Date:
September 22, 2000
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
KONNO MITOSHI (JP)
SAKAKI KATSUHITO (JP)
NAKA MASAO (JP)
KONISHI MIKIO (JP)
KISHIMOTO TADAMITSU (JP)
KONNO MITOSHI (JP)
SAKAKI KATSUHITO (JP)
NAKA MASAO (JP)
KONISHI MIKIO (JP)
KISHIMOTO TADAMITSU (JP)
International Classes:
A61K31/00; A61K31/165; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P13/12; A61P15/00; A61P17/06; A61P19/10; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07C259/06; C07C317/46; C07C323/62; C07D209/12; C07D211/22; C07D213/30; C07D263/57; C07D273/00; C07D273/01; C07D277/24; C07D295/155; C07D307/80; C07D307/91; C07D317/54; C07D333/16; C07D333/56; C07D263/56; (IPC1-7): C07C259/06; C07C317/46; C07C323/63; C07D209/18; C07D211/34; C07D213/56; C07D263/56; C07D273/01; C07D277/66; C07D295/08; C07D295/14; C07D307/38; C07D307/79; C07D307/91; C07D317/60; C07D333/24; C07D333/60; C07D413/10; A61K31/16; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/404; A61K31/42; A61K31/423; A61K31/4245; A61K31/428; A61K31/44; A61K31/445; A61K31/5375; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P13/12; A61P15/00; A61P17/06; A61P19/10; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00
Foreign References:
US4769461A | 1988-09-06 | |||
EP0737671A2 | 1996-10-16 |
Other References:
See also references of EP 1215203A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Nihonbashi-Ningyocho 2-chome Chuo-ku Tokyo, JP)
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