HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS

WIPO Patent Application WO2003057184

A3

Methods, compounds, and formulations are provided to reduce pigmentation in mammalian skin, comprising hydroxamic acid and its derivatives, and especially benzohydroxamic acid and its derivatives. The compounds preferably inhibit pigment synthesis in melanocytes through inhibition of melanocyte tyrosinase. The methods can be used for lightening skin, and for treating uneven skin complexions, which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically, and preferably as topical formulations.

JPH06706	storage containing low 誘電溶媒 -- a stable partial medicine composite
JP3703295	HAIR TREATING AGENT
WO/1999/032072	COMPOSITIONS AND METHODS FOR TREATMENT OF ALOPECIA

DOOLEY THOMAS P (US)
CHENG LIN (US)

PCT/US2002/041071

October 09, 2003

December 23, 2002

Click for automatic bibliography generation  

INTEGRIDERM INC (US)
DOOLEY THOMAS P (US)
CHENG LIN (US)

A61K8/40; A61K8/42; A61K8/49; A61K31/16; A61K31/19; A61K31/44; A61K31/4409; A61K31/455; A61Q19/02; (IPC1-7): A61K7/48; A61K31/16

WO2000056702A1	2000-09-28
WO2002024613A2	2002-03-28
WO1995001157A1	1995-01-12
WO2001064206A2	2001-09-07

US6365137B1	2002-04-02
DD293958A5	1991-09-19
US4559328A	1985-12-17
EP0199151A2	1986-10-29
US5514676A	1996-05-07

DOOLEY T P: "TOPICAL SKIN DEPIGMENTATION AGENTS: CURRENT PRODUCTS AND DISCOVERY OF NOVEL INHIBITORS OF MELANOGENESIS", JOURNAL OF DERMATOLOGICAL TREATMENT, BASINGSTOKE, GB, vol. 8, no. 4, December 1997 (1997-12-01), pages 275 - 279, XP001037520, ISSN: 0954-6634
RICH, PETER R. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 525, 1978, pages 325 - 337, XP001091256
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002243063, retrieved from STN Database accession no. 136:58529/DN, HCAPLUS
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002243064, retrieved from STN Database accession no. 96:85266/DN, HCAPLUS
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002243065, retrieved from STN Database accession no. 54:118360/DN, HCAPLUS
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243066, Database accession no. 2613864
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243067, Database accession no. 3090687
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243068, Database accession no. 5664446
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243069, Database accession no. 2576387
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243070, Database accession no. 3302271
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243071, Database accession no. 1941963
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002243072, Database accession no. 4741489
HALL I H ET AL: "THE ANTINEOPLASTIC AND CYTOTOXICITY OF BENZOHYDROXAMIC ACIDS AND RELATED DERIVATIVES IN MURINE AND HUMAN TUMOR CELLS", ANTI-CANCER DRUGS, RAPID COMMUNICATIONS, OXFORD, GB, vol. 3, no. 3, June 1992 (1992-06-01), pages 273 - 280, XP000874908, ISSN: 0959-4973
DINUNZIO, JAMES E. ET AL., JOURNAL OF CHROMATOGRAPHY, vol. 594, 1992, pages 209 - 216, XP002243062

View/Download PDF      PDF Help

Previous Patent: COMPOSITION FOR SKIN WHITENING

Next Patent: COSMETIC CLEANING AGENT FOR THE HAIR WITH EXCELLENT FOAMING AND HAIRCARE PROPERTIES