Title:
HYDROXAMIC ACIDS
Document Type and Number:
WIPO Patent Application WO/1998/015525
Kind Code:
A1
Abstract:
Hydroxamic acid derivatives represented by the following general formula and useful as a matrix metalloprotease inhibitor: R-X-B-N(R?1�)-A-CO-NHOH, wherein R is an optionally substituted cyclic hydrocarbon group or the like; X is optionally substituted alkylene or the like; B is carbonyl or the like; R?1� is hydrogen or optionally substituted lower alkyl in the case wherein B is carbonyl or sulfonyl, and R?1� is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkanoyl or the like in the case wherein B is methylene; and A is methylene substituted with one or two optionally substituted lower alkyl groups.
Inventors:
SAMIZO FUMIO (JP)
KAMIKAWA YUMIKO (JP)
SASAKI AKIRA (JP)
UEKI YASUYUKI (JP)
HOCHIGAI HITOSHI (JP)
KOGITA KIYOKO (JP)
KAMIKAWA YUMIKO (JP)
SASAKI AKIRA (JP)
UEKI YASUYUKI (JP)
HOCHIGAI HITOSHI (JP)
KOGITA KIYOKO (JP)
Application Number:
PCT/JP1997/003542
Publication Date:
April 16, 1998
Filing Date:
October 02, 1997
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
SAMIZO FUMIO (JP)
KAMIKAWA YUMIKO (JP)
SASAKI AKIRA (JP)
UEKI YASUYUKI (JP)
HOCHIGAI HITOSHI (JP)
KOGITA KIYOKO (JP)
SAMIZO FUMIO (JP)
KAMIKAWA YUMIKO (JP)
SASAKI AKIRA (JP)
UEKI YASUYUKI (JP)
HOCHIGAI HITOSHI (JP)
KOGITA KIYOKO (JP)
International Classes:
C07C259/06; C07C323/60; C07C327/48; C07D207/416; C07D209/08; C07D209/48; C07D213/56; C07D275/06; C07D471/04; C07D207/40; (IPC1-7): C07C259/06; A61K31/165; A61K31/18; A61K31/195; A61K31/275; A61K31/40; A61K31/405; A61K31/415; A61K31/425; A61K31/435; A61K31/445; A61K31/505; A61K31/535; A61K31/55; A61K31/63; C07C271/12; C07C279/04; C07C311/15; C07C311/35; C07C317/44; C07C323/60; C07D207/16; C07D207/24; C07D207/42; C07D209/08; C07D209/46; C07D209/48; C07D233/64; C07D239/84; C07D275/04; C07D295/10; C07D295/12; C07D295/14; C07D471/04
Domestic Patent References:
| WO1996020918A1 | 1996-07-11 | |||
| WO1996026223A1 | 1996-08-29 | |||
| WO1996027583A1 | 1996-09-12 |
Other References:
BIOCHEMISTRY, 25(18), (1986), MOORE WILLIAM M. et al., p. 5189-95.
PEPT. CHEM., Date 1986, 24th, (1987), NISHINO NORIKAZU et al., p. 233-236.
PEPT. CHEM., Date 1986, 24th, (1987), NISHINO NORIKAZU et al., p. 233-236.
Attorney, Agent or Firm:
Nakamura, Toshio (Legal & Patent Dept., 1-98, Kasugadenaka
3-chome, Konohana-k, Osaka-shi Osaka 554, JP)
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