(HYDROXYETHYL)UREAS AS INHIBITORS OF ALZHEIMER'S BETA-AMYLOID PRODUCTION

Title:

(HYDROXYETHYL)UREAS AS INHIBITORS OF ALZHEIMER'S BETA-AMYLOID PRODUCTION

Document Type and Number:

WIPO Patent Application WO2002014264

Kind Code:

A3

Abstract:

Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid- beta peptide. Methods are provided for administering the novel compunds to treat beta -amyloid-associated diseases, notably Alzheimer's disease.

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Inventors:

WOLFE MICHAEL S
SELKOE DENNIS J

Application Number:

PCT/US2001/025267

Publication Date:

May 30, 2002

Filing Date:

August 10, 2001

Export Citation:

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Assignee:

BRIGHAM & WOMENS HOSPITAL (US)

International Classes:

A61K31/17; A61K31/223; A61K31/47; C07C275/24; (IPC1-7): C07C275/04; A61K31/17

Domestic Patent References:

WO1992008698A1	1992-05-29
WO2001066564A2	2001-09-13
WO2002002518A2	2002-01-10

Foreign References:

DE3643977A1	1987-07-02
DE3635907A1	1988-04-28
US4599198A	1986-07-08
US2331926A	1943-10-19
US2344259A	1944-03-14
GB1046045A	1966-10-19

Other References:

KICK E K ET AL: "STRUCTURE-BASED DESIGN AND COMBINATORIAL CHEMISTRY YIELD LOW NANOMOLAR INHIBITORS OF CATHEPSIN D", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 4, no. 4, 1997, pages 297 - 307, XP002065985, ISSN: 1074-5521
CHASE, B.H. ET AL., J. PHARM. PHARMACOL., vol. 16, 1964, pages 163 - 173, XP001040339
JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 7, 1971, pages 600 - 614, XP001053530

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