Title:
HYDROXYL RADICAL SCAVENGER
Document Type and Number:
WIPO Patent Application WO/1997/004767
Kind Code:
A1
Abstract:
A hydroxyl radical scavenger which comprises as the active ingredient betaines represented by the following general formula (1) or acid-addition salts or esters thereof: (CH3)3N+(CH2)nCOO- [n = 1 to 5] and a remedy composition for diseases caused by hydroxy radicals. Because of having an excellent effect of scavenging hydroxyl radicals, this compound is useful in treating diseases, in particular, cardiac diseases caused by hydroxyl radicals.
Inventors:
KALVINSH IVARS (LV)
VEVERIS MARIS (LV)
ABIKO YASUSHI (JP)
TAJIMA KIYOTAKA (JP)
VEVERIS MARIS (LV)
ABIKO YASUSHI (JP)
TAJIMA KIYOTAKA (JP)
Application Number:
PCT/JP1996/002057
Publication Date:
February 13, 1997
Filing Date:
July 23, 1996
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
VALSTS ZINATNISKA IESTADE BEZP (LV)
KALVINSH IVARS (LV)
VEVERIS MARIS (LV)
ABIKO YASUSHI (JP)
TAJIMA KIYOTAKA (JP)
VALSTS ZINATNISKA IESTADE BEZP (LV)
KALVINSH IVARS (LV)
VEVERIS MARIS (LV)
ABIKO YASUSHI (JP)
TAJIMA KIYOTAKA (JP)
International Classes:
A61K31/197; A61K31/205; A61K31/22; A61K31/195; A61P9/00; A61P9/10; A61P17/00; A61P39/06; C07C229/12; (IPC1-7): A61K31/205; A61K31/22
Foreign References:
| JPH069386A | 1994-01-18 | |||
| JPH03115220A | 1991-05-16 | |||
| JPH02142759A | 1990-05-31 | |||
| JPS6092215A | 1985-05-23 | |||
| JPS59222412A | 1984-12-14 |
Other References:
PHYTOCHEMISTRY, Vol. 28, No. 4 (1989), SMINOFF NICHOLAS et al., "Hydroxyl Radical Scavenging Activity of Compatible Solutes", p. 1057-1058.
See also references of EP 0781554A4
See also references of EP 0781554A4
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