Title:
HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/082837
Kind Code:
A1
Abstract:
A compound represented by the following general formula (I): (I) (wherein R1 and R2 each represents optionally substituted lower alkyl) or a salt thereof. The compound or salt has calpain inhibitory activity.
Inventors:
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
INOUE JUN (JP)
Application Number:
PCT/JP2003/003910
Publication Date:
October 09, 2003
Filing Date:
March 27, 2003
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
International Classes:
A61K31/5375; A61P9/00; A61P9/10; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P37/02; A61P43/00; C07D265/32; (IPC1-7): C07D265/32; A61K31/5375; A61P9/00; A61P9/10; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P37/02; A61P43/00
Domestic Patent References:
| WO1993023032A1 | 1993-11-25 |
Foreign References:
| US6103720A | 2000-08-15 | |||
| JPH0629229B2 | 1994-04-20 | |||
| EP0771565A2 | 1997-05-07 | |||
| US6057290A | 2000-05-02 |
Other References:
ARCELLI ANTONIO ET AL.: "Unusual ammonolysis of a secondary amide assisted by unsubstituted vicinal amide group", TETRAHEDRON, vol. 52, no. 11, 1996, pages 4141 - 4148, XP004196645
LEY STEVEN V. ET AL.: "A new route to butane-1,2-deacetals and the development of alternative substitution patterns to facilitate differential protection of the products", SYNLETT, no. 11, 2001, pages 1793 - 1795, XP002970222
WANG KEVIN K.W. ET AL.: "Calpain inhibition: an overview of its therapeutic potential", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 15, 1994, pages 412 - 419, XP000568894
TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 15, 1994, pages 412
CURR. EYE RES., vol. 10, 1991, pages 657 - 666
BIOCHEM. J., vol. 253, 1988, pages 751 - 758
J. MED. CHEM., vol. 35, 1992, pages 216 - 220
LEY STEVEN V. ET AL.: "A new route to butane-1,2-deacetals and the development of alternative substitution patterns to facilitate differential protection of the products", SYNLETT, no. 11, 2001, pages 1793 - 1795, XP002970222
WANG KEVIN K.W. ET AL.: "Calpain inhibition: an overview of its therapeutic potential", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 15, 1994, pages 412 - 419, XP000568894
TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 15, 1994, pages 412
CURR. EYE RES., vol. 10, 1991, pages 657 - 666
BIOCHEM. J., vol. 253, 1988, pages 751 - 758
J. MED. CHEM., vol. 35, 1992, pages 216 - 220
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