HYDROXYPHENYL CROSS-LINKED MACROMOLECULAR NETWORK AND APPLICATIONS THEREOF

Title:

HYDROXYPHENYL CROSS-LINKED MACROMOLECULAR NETWORK AND APPLICATIONS THEREOF

Document Type and Number:

WIPO Patent Application WO2006010066

Kind Code:

A3

Abstract:

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

Inventors:

CALABRO ANTHONY (US)
AKST LEE (US)
ALAM DANIEL (US)
CHAN JAMES (US)
DARR ANIQ B (US)
FUKAMACHI KIYOTAKA (US)
GROSS RICHARD A (US)
HAYNES DAVID (US)
KAMOHARA KEIJI (US)
KNOTT DANIEL P (US)
LEWIS HILEL (US)
MELAMUD ALEX (US)
MINIACI ANTHONY (US)
STROME MARSHALL (US)

Application Number:

PCT/US2005/024391

Publication Date:

July 20, 2006

Filing Date:

July 08, 2005

Export Citation:

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Assignee:

CLEVELAND CLINIC FOUNDATION (US)
CALABRO ANTHONY (US)
AKST LEE (US)
ALAM DANIEL (US)
CHAN JAMES (US)
DARR ANIQ B (US)
FUKAMACHI KIYOTAKA (US)
GROSS RICHARD A (US)
HAYNES DAVID (US)
KAMOHARA KEIJI (US)
KNOTT DANIEL P (US)
LEWIS HILEL (US)
MELAMUD ALEX (US)
MINIACI ANTHONY (US)
STROME MARSHALL (US)

International Classes:

C08L89/00; C08G63/48; C08G63/91

Domestic Patent References:

WO2002018450A1	2002-03-07
WO2003006068A1	2003-01-23
WO2003018033A1	2003-03-06

Other References: