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Title:
HYDROXYPROPYL METHYLCELLULOSE PHTHALATE PARTICLES, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/111294
Kind Code:
A1
Abstract:
The present invention relates to hydroxypropyl methylcellulose phthalate (HPMCP) particles having a porous particle shape, and a preparation method therefor. The preparation method comprises the steps of: (1) preparing a HPMCP reaction solution; (2) injecting water into a stirring tank, which comprises a stirring device, such that the stirring device is immersed therein; (3) dropping the reaction solution into the stirring tank; and (4) allowing the dropped reaction solution to be injected into the water inside the stirring tank, in which the stirring device is operating, so as to be atomized while moving along the flow of the water. According to the present invention, the HPMCP reaction solution is injected into the water inside the stirring tank, in which the stirring device is operating, so as to be atomized, thereby enabling porous HPMCP particles to be prepared, and thus the solubility of the particles can be improved.

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Inventors:
AHN JAE HOON (KR)
SON JIN RYUL (KR)
BAE MYUNG HOON (KR)
Application Number:
PCT/KR2016/012621
Publication Date:
June 29, 2017
Filing Date:
November 04, 2016
Export Citation:
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Assignee:
LOTTE FINE CHEMICAL CO LTD (KR)
International Classes:
C08B15/02; B01J19/00; C07C67/62; C07C69/80
Foreign References:
JP4397146B22010-01-13
US3629237A1971-12-21
JP2000229227A2000-08-22
JPH10195103A1998-07-28
US3629237A1971-12-21
KR20120135063A2012-12-12
US3629237A1971-12-21
KR20120135063A2012-12-12
Other References:
ZHAO, XIUHUA ET AL.: "Preparation, Characterization, and Evaluation In Vivo of Ins-SiO2-HP55 (Insulin-loaded Silica Coating HP55) for Oral Delivery of Insulin", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 454, no. 1, 15 September 2013 (2013-09-15), pages 278 - 284, XP055508110
See also references of EP 3395838A4
Attorney, Agent or Firm:
TNI IP LAW FIRM (KR)
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