HYOSCYAMINE ALDEHYDE REDUCTASE

Title:

HYOSCYAMINE ALDEHYDE REDUCTASE

Document Type and Number:

WIPO Patent Application WO/2021/043189

Kind Code:

A1

Abstract:

Provided is a hyoscyamine aldehyde reductase with the amino acid sequence shown in SEQ ID NO. 4. Also provided are a gene, a recombinant expression vector, a transgenic cell line, and a recombinant bacteria of the hyoscyamine aldehyde reductase, the application thereof in catalysing the reduction of hyoscyamine aldehyde to produce hyoscyamine, and the application thereof in rebuilding the hyoscyamine synthesis pathway or increasing the hyoscyamine content.

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Inventors:

LIAO ZHIHUA (CN)
CHEN MING (CN)
YANG CHUNXIAN (CN)
QIU FEI (CN)
ZENG JUNLAN (CN)

Application Number:

PCT/CN2020/113138

Publication Date:

March 11, 2021

Filing Date:

September 03, 2020

Export Citation:

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Assignee:

UNIV SOUTHWEST (CN)

International Classes:

C12N15/53; C12N9/04; C12N15/82

Domestic Patent References:

WO2006010246A1

2006-02-02

Foreign References:

CN110452916A	2019-11-15
CN102399795A	2012-04-04

Other References:

QIANG WEI ,FAN YUFANG ,LIAO ZHIHUA: "Advances in Biosynthesis and Metabolic Engineering of Tropane Alkaloids", MODERNIZATION OF TRADITIONAL CHINESE MEDICINE AND MATERIA MEDICA-WORLD SCIENCE AND TECHNOLOGY, vol. 18, no. 11, 20 November 2016 (2016-11-20), pages 1899 - 1907, XP055789983, ISSN: 1674-3849, DOI: 10.11842/wst.2016.11.011
KOHNEN KATHRIN LAURA, SEZGIN SELAHADDIN, SPITELLER MICHAEL, HAGELS HANSJJORG, KAYSER OLIVER: "Localization and Organization of Scopolamine Biosynthesis in Duboisia Myoporoides R. Br", PLANT AND CELL PHSIOLOGY, vol. 59, no. 1, 31 January 2018 (2018-01-31), pages 107 - 118, XP055789985, ISSN: 0032-0781, DOI: 10.1093/pcp/pcx165

Attorney, Agent or Firm:

CHONGQING HOWDO INTELLECTUAL PROPERTY AGENCY (CN)

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