Title:
HYPERBRANCHED POLYGLYCEROL SULFATES WITH HYDROPHOBIC CORES
Document Type and Number:
WIPO Patent Application WO/2015/144722
Kind Code:
A3
Abstract:
The present invention relates to the field of drug carrier systems and polymer therapeutics and diagnostics. It provides derivatized unimolecular polyols with a hydrophobic core moiety and a polyanionic, preferably, sulfated hydrophilic shell, in particular to unimolecular hyperbranched sulfated polyglycerol micelles having a hydrophilic shell and a hydophrobic core. These may be used for the supramolecular encapsulation and transport of hydrophobic guest molecules into biological systems. The micelles can be applied as a drug carrier system for therapy and for diagnosis. They may also be therapeutic agents on their own. The invention also relates to preparation of said micelles.
Inventors:
PAULUS FLORIAN (DE)
HAAG RAINER (DE)
HAAG RAINER (DE)
Application Number:
PCT/EP2015/056287
Publication Date:
November 12, 2015
Filing Date:
March 24, 2015
Export Citation:
Assignee:
DENDROPHARM GMBH (DE)
International Classes:
C08G83/00; A61K9/107
Other References:
KAINTHAN RAJESH KUMAR ET AL: "Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 3, 10 March 2008 (2008-03-10), pages 886 - 895, XP002567890, ISSN: 1525-7797, [retrieved on 20080202], DOI: 10.1021/BM701208P
JAYANT KHANDARE ET AL: "Multifunctional dendritic polymers in nanomedicine: opportunities and challenges", CHEMICAL SOCIETY REVIEWS, vol. 41, no. 7, 1 January 2012 (2012-01-01), pages 2824, XP055136303, ISSN: 0306-0012, DOI: 10.1039/c1cs15242d
MOHIUDDIN A QUADIR ET AL: "Biofunctional nanosystems based on dendritic polymers", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 161, no. 2, 29 December 2011 (2011-12-29), pages 484 - 495, XP028492681, ISSN: 0168-3659, [retrieved on 20120105], DOI: 10.1016/J.JCONREL.2011.12.040
FREY HOLGER ET AL: "Dendritic polyglycerol: a new versatile biocompatible-material", REVIEWS IN MOLECULAR BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 90, no. 3-4, 1 May 2002 (2002-05-01), pages 257 - 267, XP002488659, ISSN: 1389-0352, DOI: 10.1016/S1389-0352(01)00063-0
ENRIQUE LALLANA ET AL: "Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 29, no. 4, 25 January 2012 (2012-01-25), pages 902 - 921, XP035025792, ISSN: 1573-904X, DOI: 10.1007/S11095-012-0683-Y
JAYANT KHANDARE ET AL: "Multifunctional dendritic polymers in nanomedicine: opportunities and challenges", CHEMICAL SOCIETY REVIEWS, vol. 41, no. 7, 1 January 2012 (2012-01-01), pages 2824, XP055136303, ISSN: 0306-0012, DOI: 10.1039/c1cs15242d
MOHIUDDIN A QUADIR ET AL: "Biofunctional nanosystems based on dendritic polymers", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 161, no. 2, 29 December 2011 (2011-12-29), pages 484 - 495, XP028492681, ISSN: 0168-3659, [retrieved on 20120105], DOI: 10.1016/J.JCONREL.2011.12.040
FREY HOLGER ET AL: "Dendritic polyglycerol: a new versatile biocompatible-material", REVIEWS IN MOLECULAR BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 90, no. 3-4, 1 May 2002 (2002-05-01), pages 257 - 267, XP002488659, ISSN: 1389-0352, DOI: 10.1016/S1389-0352(01)00063-0
ENRIQUE LALLANA ET AL: "Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 29, no. 4, 25 January 2012 (2012-01-25), pages 902 - 921, XP035025792, ISSN: 1573-904X, DOI: 10.1007/S11095-012-0683-Y
Attorney, Agent or Firm:
DF-MP DÖRRIES FRANK-MOLNIA & POHLMAN (Theatinerstraße 16, München, DE)
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