Title:
HYPERPOLARISATION IN AQUEOUS MEDIA VIA SABRE
Document Type and Number:
WIPO Patent Application WO/2018/162895
Kind Code:
A3
Abstract:
There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: • (i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; • (ii) adding H 2 or parahydrogen gas; • (iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; • (v) adding a solvent phase-separation promoter; and • (vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.
Inventors:
DUCKETT SIMON BENEDICT (GB)
IALI WISSAM (GB)
OLARU ALEXANDRA MARIA (GB)
IALI WISSAM (GB)
OLARU ALEXANDRA MARIA (GB)
Application Number:
PCT/GB2018/050573
Publication Date:
October 18, 2018
Filing Date:
March 07, 2018
Export Citation:
Assignee:
UNIV YORK (GB)
International Classes:
G01R33/56; A61K49/08; G01R33/28; C07F15/00
Domestic Patent References:
| WO2010037771A1 | 2010-04-08 |
Foreign References:
| US20080293605A1 | 2008-11-27 |
Other References:
ZENG HAIFENG ET AL: "Achieving 1% NMR polarization in water in less than 1min using SABRE", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 246, 19 July 2014 (2014-07-19), pages 119 - 121, XP029054868, ISSN: 1090-7807, DOI: 10.1016/J.JMR.2014.07.004
Attorney, Agent or Firm:
GILHOLM, Stephen Philip (GB)
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