Title:
HYPOGLYCEMIC SUBSTANCES CONTAINING ZINC
Document Type and Number:
WIPO Patent Application WO/2004/035065
Kind Code:
A1
Abstract:
It is intended to develop drugs having hypoglycemic, &agr -glucosidase inhibitory, antiinflammatory, analgesic, anticancer, antiplatelet and antithrombotic effects as well as an effect of inhibiting blood coagulation causing heart attack and apoplexy by using zinc (II) complexes containing salicylic acid, aspirin, trigonelline and derivatives thereof together with a zinc source. As a result, medicinal preparations and preventives, which have hypoglycemic, &agr -glucosidase inhibitory, antiinflammatory, analgesic, anticancer, antiplatelet and antithrombotic effects as well as an effect of inhibiting blood coagulation causing heart attack and apoplexy and comprise organic zinc (II) complexes containing, as a ligand, a compound selected from among salicylic acid having a benzene ring, trigonelline having a pyridinium ring and derivatives thereof, are successfully developed.
Inventors:
KOJIMA YOSHITANE (JP)
YOSHIKAWA YUTAKA (JP)
KAJIWARA NAEMI (JP)
SAKURAI HIROMU (JP)
TANIGUCHI HIROSHI (JP)
YOSHIKAWA YUTAKA (JP)
KAJIWARA NAEMI (JP)
SAKURAI HIROMU (JP)
TANIGUCHI HIROSHI (JP)
Application Number:
PCT/JP2003/012741
Publication Date:
April 29, 2004
Filing Date:
October 03, 2003
Export Citation:
Assignee:
ARITA JUNICHI (JP)
KOJIMA YOSHITANE (JP)
YOSHIKAWA YUTAKA (JP)
KAJIWARA NAEMI (JP)
SAKURAI HIROMU (JP)
TANIGUCHI HIROSHI (JP)
KOJIMA YOSHITANE (JP)
YOSHIKAWA YUTAKA (JP)
KAJIWARA NAEMI (JP)
SAKURAI HIROMU (JP)
TANIGUCHI HIROSHI (JP)
International Classes:
C07D213/80; A61K31/00; A61K31/4425; A61K31/555; A61K31/60; A61K31/616; A61K33/30; A61K45/06; A61P3/06; A61P3/10; A61P7/02; A61P9/02; A61P9/10; A61P9/12; A61P25/00; A61P25/04; A61P29/00; A61P35/00; A61P43/00; (IPC1-7): A61K33/30; A61K31/4425; A61K31/555; A61K31/60; A61K31/616; A61P3/10; A61P7/02; A61P25/04; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2002060432A1 | 2002-08-08 | |||
| WO2001039769A1 | 2001-06-07 | |||
| WO1987001281A1 | 1987-03-12 |
Foreign References:
| JP2003319760A | 2003-11-11 | |||
| JP2003199532A | 2003-07-15 | |||
| GB1553749A | 1979-09-26 |
Other References:
MASLENNIKOVA, I.S. ET AL: "Use of Infrared spectroscopy for determining the nature of coordination in some transition metal complexes", ZHURNAL FIZICHESKOI KHIMII, vol. 44, no. 10, 1970, pages 2509 - 2511, XP002975870
YOSHIKAWA, Y ET AL: "Studies on the development of organic zink (II) complexes with blood glucose lowering effect", BIOMED. RES. TRACE ELEMENTS, vol. 12, no. 1, 2001, pages 104 - 109, XP002975871
YOSHIKAWA, Y ET AL: "Studies on the development of organic zink (II) complexes with blood glucose lowering effect", BIOMED. RES. TRACE ELEMENTS, vol. 12, no. 1, 2001, pages 104 - 109, XP002975871
Attorney, Agent or Firm:
Miki, Hisami (3-8 Kyutaromachi 2-Chome, Chuo-k, Osaka-city Osaka, JP)
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