Title:
HYPOLIPIDEMIC BICYCLIC DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1998038182
Kind Code:
A9
Abstract:
The invention concerns compounds of formula (I) wherein: I is an integer of from 1 to 4; m is an integer of from 0 to 2; R is independently selected from hydrogen, halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R'', -CO2R'' and -O(CH2)pSO3R'' wherein p is an integer of from 1 to 4 and R'' is hydrogen or C1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms; R<1> is phenyl or pyridyl optionally substituted by one to five groups independently selected from halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R''', -CO2R''' and -O(CH2)pSO3R''' wherein p is an integer of from 1 to 4 and R''' is hydrogen or C1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms; R<2> is a group independently selected from C1-6 alkyl (including cycloalkyl and cycloalkylalkyl), C2-6 alkenyl, and C2-6 alkynyl which groups are optionally substituted by one or more groups or atoms independently selected from halogen, oxo, C1-4 alkoxy, hydroxy, amino optionally substituted by C1-6 alkyl, thio, and C1-6 alkylthio; R<3> is a group independently selected from C1-6 alkyl (including cycloalkyl and cycloalkylalkyl), C2-6 alkenyl, and C2-6 alkynyl which groups are optionally substituted by one or more groups or atoms independently selected from halogen, oxo, C1-4 alkoxy, hydroxy, amino optionally substituted by C1-6 alkyl, thio, and C1-6 alkylthio; X is CH2 or NH; Y is CH2 or O; and Z is CH or N; provided that when X is CH2, Y is O; and pharmaceutically acceptable derivatives or solvates thereof, to processes for their synthesis, to pharmaceutical compositions containing them and to their use in medicine, particularly as hypolipidemic agents.
Inventors:
HANDLON ANTHONY LOUIS (US)
HODGSON GORDON LEWIS (US)
HYMAN CLIFTON EARL (US)
HODGSON GORDON LEWIS (US)
HYMAN CLIFTON EARL (US)
Application Number:
PCT/EP1998/001078
Publication Date:
April 15, 1999
Filing Date:
February 26, 1998
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
HANDLON ANTHONY LOUIS (US)
HODGSON GORDON LEWIS (US)
HYMAN CLIFTON EARL (US)
HANDLON ANTHONY LOUIS (US)
HODGSON GORDON LEWIS (US)
HYMAN CLIFTON EARL (US)
International Classes:
C07D281/02; C07D285/36; C07D327/02; (IPC1-7): C07D285/36; A61K31/39; A61K31/55; C07D281/02; C07D291/08; C07D327/02; C07D411/04; C07D417/04; C07D419/04
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