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Title:
IAP INHIBITOR AND USE OF SAME IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2019/154053
Kind Code:
A1
Abstract:
Disclosed are a new compound that inhibits IAP and the use thereof. In particular, the present invention relates to a compound which is an IAP inhibitor, or a stereoisomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug thereof. The present invention also relates to the use of the compound and pharmaceutical composition thereof in the preparation of a drug for treating or preventing diseases caused by IAP disorder, especially the use of same in the preparation of a drug for treating or preventing cancers or hepatitis B virus infection.

Inventors:
XIE, Hongming (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
KOU, Yuhui (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
JIANG, Haigang (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
HUANG, Shihai (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
ZHANG, Yingjun (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
ZHANG, Jiancun (Dongyangguang Hi-Tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
Application Number:
CN2019/072531
Publication Date:
August 15, 2019
Filing Date:
January 21, 2019
Export Citation:
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Assignee:
SUNSHINE LAKE PHARMA CO., LTD. (Northern Industrial Area, Songshan LakeDongguan, Guangdong 0, 523000, CN)
International Classes:
C07K5/06; A61K38/00; A61P35/00; C07D403/06
Domestic Patent References:
WO2006014361A12006-02-09
WO2012080260A12012-06-21
Foreign References:
CN108440507A2018-08-24
CN101516904A2009-08-26
CN102471275A2012-05-23
CN101128425A2008-02-20
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