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Title:
IDENTIFICATION OF 5-LIPOXYGENASE AS A MAJOR GENE CONTRIBUTING TO ATHEROSCLEROSIS
Document Type and Number:
WIPO Patent Application WO2003035670
Kind Code:
A3
Abstract:
5-LO is expressed in the monocyte/macrophages (mono/mac) and foam cells of atherosclerotic lesions and is differentially expressed in CAST and CON6 mice relative to B6 mice. Mice heterozygous for a null mutation of 5-LO, when placed on an LDLR-/- background, have dramatically reduced atherosclerosis as compared to control LDLR-/- mice. In a genetic epidemiologic study, it is found that a common 5-LO polymorphism is strongly associated with carotid artery intima-media thickness (IMT). These results indicate that 5-LO is a major contributor to atherogenesis in animal models, and in atherosclerosis susceptibility in humans.

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Inventors:
MEHRABIAN MARGARETE (US)
ALLAYEE HOOMAN (US)
LUSIS ALDONS J (US)
Application Number:
PCT/US2002/034208
Publication Date:
July 10, 2003
Filing Date:
October 24, 2002
Export Citation:
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Assignee:
UNIV CALIFORNIA (US)
MEHRABIAN MARGARETE (US)
ALLAYEE HOOMAN (US)
LUSIS ALDONS J (US)
International Classes:
G01N33/50; A61K45/00; A61P7/06; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C12N15/09; C12P19/34; C12Q1/26; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12Q1/68
Other References:
MEHRABIAN M. ET AL.: "Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice", CIRCULATION RESEARCH, vol. 91, 2002, pages 120 - 126, XP002962779
IN K.H. ET AL.: "Naturally occuring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription", JOURNAL OF CLINICAL INVESTIGATION, vol. 99, March 1997 (1997-03-01), pages 1130 - 1137, XP002145101
See also references of EP 1448794A4
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