Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
IDENTIFICATION OF HLA-DR4 EPITOPE AND USE FOR TREATMENT OF ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2011/071039
Kind Code:
A1
Abstract:
Provided are novel means for determining the amino acid sequence structure of a specific antigen polypeptide (epitope) presented by RA-sensitive MHC class II molecules, such as HLA-DR4 or HLA-DR1, with respect to CD4-positive T cells, and for preventing or treating disease associated with HLA-DR4 or HLA-DR1, including rheumatoid arthritis, using this type of epitope. It is clarified that a polypeptide which is formed from a total of 12 to 20 amino acid residues and includes a specific amino acid sequence motif comprising the amino acid sequence X1 X2 X3 X4 X5 X6 X7 X8 X9 X10 X11 X12 (Seq. ID No. 1) is an epitope presented by HLA-DR4 or HLA-DR1.

Inventors:
SHODA HIROFUMI (JP)
FUJIO KEISHI (JP)
YAMAMOTO KAZUHIKO (JP)
Application Number:
JP2010/071901
Publication Date:
June 16, 2011
Filing Date:
December 07, 2010
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV TOKYO (JP)
SHODA HIROFUMI (JP)
FUJIO KEISHI (JP)
YAMAMOTO KAZUHIKO (JP)
International Classes:
C07K7/08; A61K38/00; A61K39/00; A61K48/00; A61P3/10; A61P19/02; A61P25/00; A61P29/00; A61P37/02; C12N15/09
Foreign References:
EP1332760A12003-08-06
JP2009525727A2009-07-16
JP2003523167A2003-08-05
Other References:
KEISHI FUJIO ET AL.: "Kansetsu Rheumatism ni Kanren suru Jiko Kogen ni Taisuru T Saibo Men'eki Oto no Kaiseki ni Kansuru Kenkyu", KOSEI RODO KAGAKU KENKYUHI HOJOKIN MEN'EKI ALLERGY SHIKKAN YOBO ยท CHIRYO KENKYU JIGYO KANSETSU RHEUMATISM NO SOKI SHINDAN NI YORU HASSHO OYOBI JUSHOKA YOBO, 23 March 2009 (2009-03-23), pages 83 - 84
TING J. ET AL.: "Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation", DNA, vol. 7, no. 4, 1988, pages 275 - 286, XP000877141
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Download PDF: