IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS

Title:

IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS

Document Type and Number:

WIPO Patent Application WO/2011/130749

Kind Code:

A3

Abstract:

The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can directly infect cells through interaction with cell proteins other than typical mediators of HSV infection. In another aspect, the invention provides an HSV vector, which exhibits lateral spread in cells typically resistant to HSV lateral spread, such as cells lacking gD receptors. The invention further provides DNA encoding mutant forms of the HSV gB and gH glycoproteins, stocks of the inventive virus, and methods for effecting viral targeting and efficient entry of cells. The invention also pertains to the use of the inventive vectors for treating cancers.

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Inventors:

GLORIOSO III JOSEPH C (US)
UCHIDA HIROAKI (US)
COHEN JUSTUS B (US)

Application Number:

PCT/US2011/032923

Publication Date:

May 24, 2012

Filing Date:

April 18, 2011

Export Citation:

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Assignee:

UNIV PITTSBURGH (US)
GLORIOSO III JOSEPH C (US)
UCHIDA HIROAKI (US)
COHEN JUSTUS B (US)

International Classes:

C12N15/869; A61P35/00; C12N15/38

Domestic Patent References:

WO2008141151A2	2008-11-20
WO2009148488A2	2009-12-10

Foreign References:

US20020037575A1	2002-03-28
KR20030047667A	2003-06-18

Other References:

JULIA O. JACKSON ET AL.: "Insertion Mutations in Herpes Simplex Virus 1 Glycoprotein H Reduce Cell Surface Expression, Slow the Rate of Cell Fusion, or Abrogate Functions in Cell Fusion and Viral Entry", JOURNAL OF VIROLOGY, vol. 84, no. 4, February 2010 (2010-02-01), pages 2038 - 2046

Attorney, Agent or Firm:

HEFNER, M. Daniel et al. (VOIT & MAYER LTD.,180 North Stetson Avenue,Suite 490, Chicago Illinois, US)

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