Title:
IDENTIFICATION OF NEURAL DEFECTS ASSOCIATED WITH THE GENE
Document Type and Number:
WIPO Patent Application WO2001085995
Kind Code:
A9
Abstract:
A method for screening neural system defects in a human comprises: (A) providing chromosomal material from the human; (B) detecting a modification of the NAP1L2 gene in the chromosomal material, wherein the modification is selected from a) substitution, b) dele-tion, c) frame-shift, or d) insertion that causes a loss of biological function in the NAP1L2 gene; and (C) correlating the modification of the gene with a potential for a neural system defect. The method can also be practiced with the mouseNap1L2 gene.
Inventors:
AVNER PHILIP (FR)
ROGNER UTE CHRISTINE (FR)
SPYROPOULOS DEMETRI (US)
ROUGEULLE CLAIRE (FR)
ROGNER UTE CHRISTINE (FR)
SPYROPOULOS DEMETRI (US)
ROUGEULLE CLAIRE (FR)
Application Number:
PCT/IB2001/000960
Publication Date:
August 15, 2002
Filing Date:
May 04, 2001
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
CENTRE NAT RECH SCIENT (FR)
AVNER PHILIP (FR)
ROGNER UTE CHRISTINE (FR)
SPYROPOULOS DEMETRI (US)
ROUGEULLE CLAIRE (FR)
CENTRE NAT RECH SCIENT (FR)
AVNER PHILIP (FR)
ROGNER UTE CHRISTINE (FR)
SPYROPOULOS DEMETRI (US)
ROUGEULLE CLAIRE (FR)
International Classes:
G01N33/48; A61K45/00; A61P25/00; A61P35/00; C12N5/10; C12N15/09; C12Q1/68; C12Q1/6883; G01N33/15; G01N33/50; G01N33/53; (IPC1-7): C12Q1/68
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