Title:
IDENTIFICATION OF AND TREATMENT FOR PERSONS AT HIGH RISK FOR DEVELOPING MAJOR DEPRESSIVE DISORDER
Document Type and Number:
WIPO Patent Application WO/2019/140355
Kind Code:
A1
Abstract:
This invention relates to the field of treatment, prevention, and identification of persons at high risk of developing major depressive disorder based upon elevated concentration of serotonin 1A receptors (i.e., elevated serotonin 1A receptor binding potential). In particular, the current invention identifies offspring of parents with major depressive disorder who are at significantly elevated risk of developing major depressive disorder before any symptoms have occurred and treats these patients prior to any symptoms and more importantly before developing major depressive disorder. The invention also relates to the identification of persons who have discontinued treatment for major depressive disorder based upon elevated concentration of serotonin 1A receptors (i.e., elevated serotonin 1A receptor binding potential).
Inventors:
MILAK MATTHEW (US)
MANN J (US)
MANN J (US)
Application Number:
PCT/US2019/013448
Publication Date:
July 18, 2019
Filing Date:
January 14, 2019
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
G01N33/94; G01N33/48; G01N33/50
Other References:
SULLIVAN, GM, MD: "Positron Emission Tomography Quantification of Serotonin1A Receptor Binding in Suicide Attempters With Major Depressive Disorder", JAMA PSYCHIATRY, vol. 72, no. 2, 30 December 2014 (2014-12-30), pages 169 - 178, XP055624628
KAUFMAN, J ET AL.: "Quantification of the Serotonin 1A Receptor Using PET: Identification of A Potential Biomarker of Major Depression in Males", NEUROPSYCHOPHARMACOLOGY, vol. 40, no. 7, 11 February 2015 (2015-02-11), pages 1692 - 1699, XP055624630
GRAY, NA ET AL.: "Antidepressant Treatment Reduces Serotonin-1A Autoreceptor Binding in Major Depressive Disorder", BIOLOGICAL PSYCHIATRY, vol. 74, no. 1, 1 July 2013 (2013-07-01), pages 26 - 31, XP028570859, DOI: 10.1016/j.biopsych.2012.11.012
MILAK, MS ET AL.: "Pretreatment Regional Brain Glucose Uptake in the Midbrain On PET May Predict Remission from A Major Depressive Episode After Three Months of Treatment", PSYCHIATRY RESEARCH: NEUROIMAGING, vol. 173, no. 1, 15 July 2009 (2009-07-15), pages 63 - 70, XP026144750, DOI: 10.1016/j.pscychresns.2008.09.004
KAUFMAN, J ET AL.: "Quantification of the Serotonin 1A Receptor Using PET: Identification of A Potential Biomarker of Major Depression in Males", NEUROPSYCHOPHARMACOLOGY, vol. 40, no. 7, 11 February 2015 (2015-02-11), pages 1692 - 1699, XP055624630
GRAY, NA ET AL.: "Antidepressant Treatment Reduces Serotonin-1A Autoreceptor Binding in Major Depressive Disorder", BIOLOGICAL PSYCHIATRY, vol. 74, no. 1, 1 July 2013 (2013-07-01), pages 26 - 31, XP028570859, DOI: 10.1016/j.biopsych.2012.11.012
MILAK, MS ET AL.: "Pretreatment Regional Brain Glucose Uptake in the Midbrain On PET May Predict Remission from A Major Depressive Episode After Three Months of Treatment", PSYCHIATRY RESEARCH: NEUROIMAGING, vol. 173, no. 1, 15 July 2009 (2009-07-15), pages 63 - 70, XP026144750, DOI: 10.1016/j.pscychresns.2008.09.004
Attorney, Agent or Firm:
CARNEY, Bonnie, K. et al. (US)
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