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Title:
IDENTIFICATION AND UTILIZATION OF CHONDROITIN POLYMERIZATION FACTOR
Document Type and Number:
WIPO Patent Application WO/2004/078969
Kind Code:
A1
Abstract:
A novel gene participating in the polymerization of chondroitin chain is found out. A gene product thereof, which forms a complex with chondroitin synthase in vivo and thus promotes polymerization of chondroitin, is named chondroitin polymerization factor (ChPF). This chondroitin polymerization factor is usable in artificially synthesizing sugar chain skeletons of sulfated glycosaminoglycans having useful physiological activities such as chondroitin sulfate and dermatan sulfate, which makes it industrially useful.

Inventors:
SUGAHARA KAZUYUKI (JP)
KITAGAWA HIROSHI (JP)
Application Number:
PCT/JP2004/002893
Publication Date:
September 16, 2004
Filing Date:
March 05, 2004
Export Citation:
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Assignee:
NEW IND RES ORGANIZATION (JP)
SUGAHARA KAZUYUKI (JP)
KITAGAWA HIROSHI (JP)
International Classes:
C12N9/10; C12P19/26; G01N33/68; (IPC1-7): C12N15/09; A01K67/027; C12P19/04; C12Q1/68; G01N33/50
Domestic Patent References:
WO1999063088A21999-12-09
WO2003102194A12003-12-11
Other References:
(SUPERVISED BY) IMAHORI KAZUTOMO ET AL., SEIKAGAKU JITEN (3RD EDITION), 20 November 1998 (1998-11-20), TOKYO KAGAKU DOJIN, pages 556 - 557, 941, XP002979680
NAKAMURA Y. ET AL.: "Identification of a drosophilia gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 48, 29 November 2002 (2002-11-29), pages 46280 - 46288, XP002903671
Attorney, Agent or Firm:
Tsuburaya, Toru (Osaka Ekimae Dai-3 Bldg. 1-1-3, Umeda, Kita-k, Osaka-shi Osaka 01, JP)
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