IG E DETECTION AND ALLERGY DIAGNOSTIC METHOD USING ENZYME-MIMETIC NANOZYME-BASED IMMUNOASSAY

Title:

IG E DETECTION AND ALLERGY DIAGNOSTIC METHOD USING ENZYME-MIMETIC NANOZYME-BASED IMMUNOASSAY

Document Type and Number:

WIPO Patent Application WO/2018/084340

Kind Code:

A1

Abstract:

The present invention relates to: enzyme-mimetic nanoparticles for allergy diagnosis; a lateral flow chromogenic chip using the enzyme-mimetic nanoparticles for allergy diagnosis, and a manufacturing method therefor; and an immunoplate method and kit for allergy diagnosis, using the enzyme-mimetic nanoparticles for allergy diagnosis. To this end, one aspect of the present invention provides enzyme-mimetic nanoparticles for allergy diagnosis, having a first anti-IgE antibody labeled on the surface thereof by physical bonding, being monodisperse, and comprising an inorganic metal catalyst oxidizing a chromogenic substrate. According to the present invention, provided are a lateral flow chromogenic chip for allergy diagnosis and an immunoplate kit for allergy diagnosis, the chip and the kit: enhancing the stability of a diagnostic kit by using an inorganic metal catalyst-based diagnostic immunoassay method having alleviated enzymatic instability and variability caused by a temperature change and a pH change, which are the problems of a conventional enzyme-based diagnostic immunoassay method; reducing examination time; and improving economic feasibility by reducing costs for each of the processes of manufacturing, transportation, storage, and examination.

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Inventors:

LEE SANG PYO (KR)
LEE SANG MIN (KR)
KIM MOON IL (KR)
SHIN HO YUN (KR)
LEE JINWOO (KR)
KIM MIN SU (KR)

Application Number:

PCT/KR2016/012685

Publication Date:

May 11, 2018

Filing Date:

November 04, 2016

Export Citation:

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Assignee:

GIL MEDICAL CT (KR)
UNIV GACHON IND ACAD COOP FOUND (KR)
POSTECH ACAD IND FOUND (KR)

International Classes:

G01N33/564; B01J23/52; B01J23/745; G01N33/532; G01N33/543; G01N33/558

Foreign References:

KR20150092443A	2015-08-13
US8993347B2	2015-03-31
US6824975B2	2004-11-30
CN102331492A	2012-01-25

Other References:

LEE, S. P. ET AL.: "Highly Sensitive Colorimetric Detection of Allergy Based on Immunoassay Using Enzyme-mimicking Nanoparticles", POSTER PRESENTATION, 6 May 2016 (2016-05-06)

Attorney, Agent or Firm:

LEE, Un Cheol (KR)

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