Title:
IGM COMPOSITIONS AND METHODS OF MUCOSAL DELIVERY OF THESE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2019/212603
Kind Code:
A3
Abstract:
Described herein are methods of inducing an immune response directed towards preventing or reducing the risk of a human immunodeficiency virus (HIV) infection in a mammalian subject. The subject is administered an effective amount of a composition containing IgM antibodies directed to an epitope of an envelope protein of the HIV virus. Also disclosed here are vaccine compositions comprising IgM antibodies directed to one or more epitopes of one or more human immunodeficiency virus envelope proteins. Also disclosed are recombinant immunoglobulin M compositions containing a Fcγ fragment of an immunoglobulin G.
Inventors:
RUPRECHT RUTH (US)
GONG SIQI (US)
GONG SIQI (US)
Application Number:
PCT/US2019/000022
Publication Date:
January 02, 2020
Filing Date:
May 06, 2019
Export Citation:
Assignee:
TEXAS BIOMEDICAL RES INSTITUTE (US)
International Classes:
A61K38/00; A61K31/7088; A61K38/16
Foreign References:
| US5618922A | 1997-04-08 | |||
| US5691135A | 1997-11-25 | |||
| US20160244510A1 | 2016-08-25 |
Attorney, Agent or Firm:
PERUMAL, Karthika (US)
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