Title:
IL-1 BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2014/011955
Kind Code:
A3
Abstract:
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.
Inventors:
LACY SUSAN E (US)
BENATUIL LORENZO (US)
CHHAYA MEHA (US)
FUNG EMMA (US)
MILLER RENEE (US)
CHARI RAVI (US)
HEIGHTON SARAH J (US)
BIXBY JACQUELINE G (US)
BENATUIL LORENZO (US)
CHHAYA MEHA (US)
FUNG EMMA (US)
MILLER RENEE (US)
CHARI RAVI (US)
HEIGHTON SARAH J (US)
BIXBY JACQUELINE G (US)
Application Number:
PCT/US2013/050197
Publication Date:
March 06, 2014
Filing Date:
July 12, 2013
Export Citation:
Assignee:
ABBVIE INC (US)
International Classes:
C07K16/24
Foreign References:
| AU2012200225A1 | 2012-02-02 |
Other References:
WU CHENGBIN ET AL: "Molecular construction and optimization of anti-human IL-1 alpha/beta dual variable domain immunoglobulin (DVD-Ig (TM)) molecules", MABS, vol. 1, no. 4, July 2009 (2009-07-01), pages 339 - 347, XP002717469, ISSN: 1942-0862
WU CHENGBIN ET AL: "Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 25, no. 11, 1 November 2007 (2007-11-01), pages 1290 - 1297, XP009110104, ISSN: 1087-0156, DOI: 10.1038/NBT1345
KONTERMANN ROLAND E: "Dual targeting strategies with bispecific antibodies", MABS, LANDES BIOSCIENCE, US, vol. 4, no. 2, 1 March 2012 (2012-03-01), pages 182 - 197, XP002698995, ISSN: 1942-0862, DOI: 10.4161/MABS.4.2.19000
ALAIN BECK ET AL: "Strategies and challenges for the next generation of therapeutic antibodies", NATURE REVIEWS IMMUNOLOGY, vol. 10, no. 5, 1 May 2010 (2010-05-01), pages 345 - 352, XP055012390, ISSN: 1474-1733, DOI: 10.1038/nri2747
DIGIAMMARINO ENRICO ET AL: "Design and generation of DVD-Ig(TM) molecules for dual-specific targeting", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS, INC, US, vol. 899, 1 January 2012 (2012-01-01), pages 145 - 156, XP009169361, ISSN: 1940-6029, DOI: 10.1007/978-1-61779-921-1_9
WU CHENGBIN ET AL: "Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 25, no. 11, 1 November 2007 (2007-11-01), pages 1290 - 1297, XP009110104, ISSN: 1087-0156, DOI: 10.1038/NBT1345
KONTERMANN ROLAND E: "Dual targeting strategies with bispecific antibodies", MABS, LANDES BIOSCIENCE, US, vol. 4, no. 2, 1 March 2012 (2012-03-01), pages 182 - 197, XP002698995, ISSN: 1942-0862, DOI: 10.4161/MABS.4.2.19000
ALAIN BECK ET AL: "Strategies and challenges for the next generation of therapeutic antibodies", NATURE REVIEWS IMMUNOLOGY, vol. 10, no. 5, 1 May 2010 (2010-05-01), pages 345 - 352, XP055012390, ISSN: 1474-1733, DOI: 10.1038/nri2747
DIGIAMMARINO ENRICO ET AL: "Design and generation of DVD-Ig(TM) molecules for dual-specific targeting", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS, INC, US, vol. 899, 1 January 2012 (2012-01-01), pages 145 - 156, XP009169361, ISSN: 1940-6029, DOI: 10.1007/978-1-61779-921-1_9
Attorney, Agent or Firm:
VELEMA, James, H. et al. (28 State StreetBoston, MA, US)
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