IL-18 BINDING PROTEINS

WIPO Patent Application WO2005047307

A3

The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

GHAYUR TARIQ (US)
LABKOVSKY BORIS (US)
VOSS JEFFREY W (US)
GREEN LARRY (US)
BABCOOK JOHN (CA)
JIA XIAO-CHI (US)
WIELER JAMES (US)
KANG JASPAL SINGH (CA)
HEDBERG BRAD (CA)

PCT/US2004/037971

August 31, 2006

November 12, 2004

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ABBOTT LAB (US)
GHAYUR TARIQ (US)
LABKOVSKY BORIS (US)
VOSS JEFFREY W (US)
GREEN LARRY (US)
BABCOOK JOHN (CA)
JIA XIAO-CHI (US)
WIELER JAMES (US)
KANG JASPAL SINGH (CA)
HEDBERG BRAD (CA)

C07K16/00; A61K39/395; C07H21/04; C07K16/24; C12N15/00; G01N33/53; G01N33/68

KOHKA H. ET AL.: "Involvement of Interleukin-18 (IL-18) in Mixed Lymphocyte Reactions (MLR)", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, vol. 19, 1999, pages 1053 - 1057, XP001007317

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