Title:
IL-2 VARIANTS AND FUSION PROTEINS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046156
Kind Code:
A1
Abstract:
Provided are IL-2 variants and polypeptide complexes comprising the IL-2 variants, the methods of producing the same and the uses thereof. The IL-2 variants and fusion proteins can be used as a potent agent for the treatment of cancers, autoimmune and inflammatory diseases.
Inventors:
WU LEI (CN)
XU JIANQING (CN)
SUN MENGMENG (CN)
WANG SHUANG (CN)
GU JIJIE (CN)
XU JIANQING (CN)
SUN MENGMENG (CN)
WANG SHUANG (CN)
GU JIJIE (CN)
Application Number:
PCT/CN2022/121283
Publication Date:
March 30, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
C12N15/26; A61K38/17; A61K38/20; A61P37/04; C07K14/55; C07K19/00; C12N15/62
Domestic Patent References:
| WO2020125743A1 | 2020-06-25 |
Foreign References:
| CN111647068A | 2020-09-11 | |||
| CN111018961A | 2020-04-17 | |||
| CN110392692A | 2019-10-29 | |||
| CN101426916A | 2009-05-06 | |||
| CN101166823A | 2008-04-23 | |||
| CN103492411A | 2014-01-01 | |||
| CN110325205A | 2019-10-11 | |||
| CN113383013A | 2021-09-10 | |||
| TW202043259A | 2020-12-01 | |||
| US20120244112A1 | 2012-09-27 | |||
| CN112210000A | 2021-01-12 | |||
| CN111334546A | 2020-06-26 |
Other References:
DATABASE Protein NCBI; ANONYMOUS : "Interleukin 2 [Homo sapiens]", XP093054489
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF: