Title:
IL-33 ANTAGONIST-CONTAINING THERAPEUTIC AGENT FOR ENDOMETRIOSIS
Document Type and Number:
WIPO Patent Application WO/2019/045075
Kind Code:
A1
Abstract:
To provide a therapeutic agent for endometriosis and adenomyosis. IL-33 was identified as an exacerbating factor in endometriosis and adenomyosis, and an IL-33 antagonist, which is capable of inhibiting the function of IL-33, was found to be useful for treating, preventing or alleviating endometriosis and uterine adenomyosis.
Inventors:
YOSHIMOTO TOMOHIRO (JP)
PALUMBO M JOSEPH (US)
STONE I VIOLETTA (US)
KATO TORU (JP)
YASUDA KOUBUN (JP)
PALUMBO M JOSEPH (US)
STONE I VIOLETTA (US)
KATO TORU (JP)
YASUDA KOUBUN (JP)
Application Number:
PCT/JP2018/032494
Publication Date:
March 07, 2019
Filing Date:
August 31, 2018
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
HYOGO COLLEGE MEDICINE (JP)
HYOGO COLLEGE MEDICINE (JP)
International Classes:
A61K45/00; A61K38/17; A61K39/395; A61K47/68; A61P15/00; C07K16/24; C07K19/00; C12N15/113
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Foreign References:
| EP0125023A1 | 1984-11-14 |
Other References:
MILLER, J. E. ET AL.: "Pro-inflammatory effects of IL -33 in endometriosis", REPRODUCTIVE SCIENCES, vol. 24, no. 1, 1 March 2017 (2017-03-01), pages 270A, XP009519346, ISSN: 1933-7191
SANTULLI, P. ET AL.: "Serum and peritoneal inter leukin-33 levels and elevated in deeply infiltrating endometriosis", HUMAN REPRODUCTION, vol. 27, no. 7, 2012, pages 2001 - 2009, XP055574522
MBARIK, M. ET AL.: "Soluble ST2 and IL -33: Potential markers of endometriosis in the Tunisian population", IMMUNOLOGY LETTER S, vol. 166, 2015, pages 1 - 5, XP055579497
MILLER, J. E. ET AL.: "Inter leukin-33 modulates inflammation in endometriosis", REPRODUCTIVE SCIENCES, vol. 25, no. 1, 28 February 2018 (2018-02-28), pages 287A - 288A, XP009519347, ISSN: 1933-7191
MILLER, J. E. ET AL.: "Inter leukin-33 modulates inflammation in endometriosis", SCIENTIFIC REPORTS, vol. 7, no. 1, 20 December 2017 (2017-12-20), pages 1 - 11, XP055579506
TATSUKUNI OHNO ET AL., ALLERGY, vol. 67, 2012, pages 1203
MARUOA MBARIK ET AL., IMMUNOL. LETT., vol. 166, 2015, pages l
CLIFFORD MINTZ ET AL., BIOPROCESS INTERNATIONAL, vol. 11, no. 2, 2013, pages 40 - 48
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, US DEPARTMENT OF HEALTH AND HUMAN SERVICES, NIH
BIBEROGLU, KOBEHRMAN, SJ, AM. J. OBSTET. GYNECOL., vol. 139, 1981, pages 645
JONES, G. ET AL., OBSTET. GYNECOL., vol. 98, 2001, pages 258
BROOKS, R. ET AL., HEALTH POLICY, vol. 37, 1997, pages 53
DEAL, LS ET AL., QUAL. LIFE RES., vol. 19, no. 6, 2010, pages 899
BORREBAECK, C.A.K.LARRICK, J.W.: "Therapeutic Monoclonal Antibodies", 1990, MACMILLAN PUBLISHERS, LTD.
KOZBOR ET AL., IMMUNOL. TODAY, vol. 4, 1983, pages 72
COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, INC., pages: 77
WU ET AL., NATURE BIOTECHNOLOGY, vol. 25, no. 11, 2007, pages 1290
KITAZAWA ET AL., NATURE MEDICINE, vol. 18, no. 10, 2012, pages 1570
CLIFFORD MINTZ ET AL., BIOPROCESSES INTERNATIONAL, vol. 11, no. 2, 2013, pages 40 - 48
HIPOLITO ET AL., CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 16, 2012, pages 196
YAMAGISHI ET AL., CHEMISTRY & BIOLOGY, vol. 18, 2011, pages 1562
KING, D.J.: "Applications and Engineering of Monoclonal Antibodies", 1998, T.J. INTERNATIONAL LTD.
CHARI ET AL., CANCER RES., vol. 152, 1992, pages 127
LIU ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 8681
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
ED HARLOWDAVID LANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
RICCI ET AL., REPROD. SCI., vol. 18, 2011, pages 614
YASUDA ET AL., PNAS, vol. 130, 2012, pages 184
KONDO ET AL., INT. IMMUNOL., vol. 20, 2008, pages 791
See also references of EP 3677281A4
SANTULLI, P. ET AL.: "Serum and peritoneal inter leukin-33 levels and elevated in deeply infiltrating endometriosis", HUMAN REPRODUCTION, vol. 27, no. 7, 2012, pages 2001 - 2009, XP055574522
MBARIK, M. ET AL.: "Soluble ST2 and IL -33: Potential markers of endometriosis in the Tunisian population", IMMUNOLOGY LETTER S, vol. 166, 2015, pages 1 - 5, XP055579497
MILLER, J. E. ET AL.: "Inter leukin-33 modulates inflammation in endometriosis", REPRODUCTIVE SCIENCES, vol. 25, no. 1, 28 February 2018 (2018-02-28), pages 287A - 288A, XP009519347, ISSN: 1933-7191
MILLER, J. E. ET AL.: "Inter leukin-33 modulates inflammation in endometriosis", SCIENTIFIC REPORTS, vol. 7, no. 1, 20 December 2017 (2017-12-20), pages 1 - 11, XP055579506
TATSUKUNI OHNO ET AL., ALLERGY, vol. 67, 2012, pages 1203
MARUOA MBARIK ET AL., IMMUNOL. LETT., vol. 166, 2015, pages l
CLIFFORD MINTZ ET AL., BIOPROCESS INTERNATIONAL, vol. 11, no. 2, 2013, pages 40 - 48
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, US DEPARTMENT OF HEALTH AND HUMAN SERVICES, NIH
BIBEROGLU, KOBEHRMAN, SJ, AM. J. OBSTET. GYNECOL., vol. 139, 1981, pages 645
JONES, G. ET AL., OBSTET. GYNECOL., vol. 98, 2001, pages 258
BROOKS, R. ET AL., HEALTH POLICY, vol. 37, 1997, pages 53
DEAL, LS ET AL., QUAL. LIFE RES., vol. 19, no. 6, 2010, pages 899
BORREBAECK, C.A.K.LARRICK, J.W.: "Therapeutic Monoclonal Antibodies", 1990, MACMILLAN PUBLISHERS, LTD.
KOZBOR ET AL., IMMUNOL. TODAY, vol. 4, 1983, pages 72
COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, INC., pages: 77
WU ET AL., NATURE BIOTECHNOLOGY, vol. 25, no. 11, 2007, pages 1290
KITAZAWA ET AL., NATURE MEDICINE, vol. 18, no. 10, 2012, pages 1570
CLIFFORD MINTZ ET AL., BIOPROCESSES INTERNATIONAL, vol. 11, no. 2, 2013, pages 40 - 48
HIPOLITO ET AL., CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 16, 2012, pages 196
YAMAGISHI ET AL., CHEMISTRY & BIOLOGY, vol. 18, 2011, pages 1562
KING, D.J.: "Applications and Engineering of Monoclonal Antibodies", 1998, T.J. INTERNATIONAL LTD.
CHARI ET AL., CANCER RES., vol. 152, 1992, pages 127
LIU ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 8681
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
ED HARLOWDAVID LANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
RICCI ET AL., REPROD. SCI., vol. 18, 2011, pages 614
YASUDA ET AL., PNAS, vol. 130, 2012, pages 184
KONDO ET AL., INT. IMMUNOL., vol. 20, 2008, pages 791
See also references of EP 3677281A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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