Title:
IL-6 PRODUCTION INHIBITOR, ANTI-INFLAMMATORY AGENT, ANTI-NEURODEGENERATIVE DISEASE AGENT, ANTI-NEUROPSYCHIATRIC DISEASE AGENT, MEDICINE AND FOOD
Document Type and Number:
WIPO Patent Application WO/2018/029793
Kind Code:
A1
Abstract:
An IL-6 production inhibitor which comprises rhinacanthin C alone as an active ingredient and inhibits IL-6 production in microglia. An anti-inflammatory agent which comprises rhinacanthin C alone as an active ingredient and inhibits IL-6 production in microglia to thereby prevent or suppress inflammation in the central nervous system. An anti-neurodegenerative disease agent or an anti-neuropsychiatric disease agent which comprises the IL-6 production inhibitor or anti-inflammatory agent as described above as an active ingredient. A medicine or a food which comprises the IL-6 production inhibitor, anti-inflammatory agent, anti-neurodegenerative disease agent or anti-neuropsychiatric disease agent as described above. According to the present invention, the IL-6 production inhibitor, anti-inflammatory agent, anti-neurodegenerative disease agent, anti-neuropsychiatric disease agent, medicine and food each using rhinacanthin C, which is clarified as having an inhibitory effect on IL-6 production in microglia, can be provided.
Inventors:
TAKAHASHI TOMOYA (JP)
PAN I HORNG (TW)
WEN SHU FANG (TW)
LU I HUANG (TW)
CHUANG KAI AN (TW)
LI MING HAN (TW)
PERNG MING DER (TW)
PAN I HORNG (TW)
WEN SHU FANG (TW)
LU I HUANG (TW)
CHUANG KAI AN (TW)
LI MING HAN (TW)
PERNG MING DER (TW)
Application Number:
PCT/JP2016/073506
Publication Date:
February 15, 2018
Filing Date:
August 09, 2016
Export Citation:
Assignee:
AOB KEIOH GROUP CORP (JP)
International Classes:
A61K31/122; A23L33/10; A61P9/10; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P29/00; A61P43/00
Other References:
BHUSAL, N. ET AL.: "In vivo analgesic and anti-inflammatory activities of a standardized Rhinacanthus nasutus leaf extract in comparison with its major active constituent rhinacanthin- C", SONGKLANAKARIN J, SCI. TECHNOL., vol. 36, no. 3, 2014, pages 325 - 331, XP055603106, ISSN: 0125-3395, Retrieved from the Internet [retrieved on 20160829]
SHINJI SAIKI ET AL: "Ens ho to Shinkei Hensei 3-6 Parkinson-byo to Ensho", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 248, no. 12, 22 March 2014 (2014-03-22), pages 897 - 900
CHATURVEDI, R. K. ET AL.: "PPAR: a therapeutic target in Parkinson' s disease", J. NEUROCHEM., vol. 106, no. 2, July 2008 (2008-07-01), pages 506 - 518, XP002569988, ISSN: 0022-3042
TOGNA, A.R. ET AL.: "4-Methylcoumarin Derivatives with Anti- inflammatory Effects in Activated Microglial Cells", BIOL. PHARM. BULL., vol. 37, no. 1, January 2014 (2014-01-01), pages 60 - 66, XP055603110, ISSN: 0918-6158
TIZABI, Y. ET AL.: "Relevance of the Anti-Inflammatory Propert ies of Curcumin in Neurodegenerative Diseases and Depression", MOLECULES, vol. 19, no. 12, 12 December 2014 (2014-12-12), pages 20864 - 20879, XP055603111, ISSN: 1420-3049, Retrieved from the Internet [retrieved on 20160829]
KENJI HASHIMOTO: "2.Prevention of schizophrenia by antioxidant and anti-inflammatory compounds", JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY, vol. 26, no. 1, 1 March 2015 (2015-03-01), pages 34 - 37
SHINJI SAIKI ET AL: "Ens ho to Shinkei Hensei 3-6 Parkinson-byo to Ensho", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 248, no. 12, 22 March 2014 (2014-03-22), pages 897 - 900
CHATURVEDI, R. K. ET AL.: "PPAR: a therapeutic target in Parkinson' s disease", J. NEUROCHEM., vol. 106, no. 2, July 2008 (2008-07-01), pages 506 - 518, XP002569988, ISSN: 0022-3042
TOGNA, A.R. ET AL.: "4-Methylcoumarin Derivatives with Anti- inflammatory Effects in Activated Microglial Cells", BIOL. PHARM. BULL., vol. 37, no. 1, January 2014 (2014-01-01), pages 60 - 66, XP055603110, ISSN: 0918-6158
TIZABI, Y. ET AL.: "Relevance of the Anti-Inflammatory Propert ies of Curcumin in Neurodegenerative Diseases and Depression", MOLECULES, vol. 19, no. 12, 12 December 2014 (2014-12-12), pages 20864 - 20879, XP055603111, ISSN: 1420-3049, Retrieved from the Internet
KENJI HASHIMOTO: "2.Prevention of schizophrenia by antioxidant and anti-inflammatory compounds", JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY, vol. 26, no. 1, 1 March 2015 (2015-03-01), pages 34 - 37
Attorney, Agent or Firm:
MATSUO, Nobutaka (JP)
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