Title:
IL33 PROTEINS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/081802
Kind Code:
A3
Abstract:
In some embodiments the present invention provides methods and compositions for inducing the formation of de novo tertiary lymphoid structures in subjects. In some embodiments such methods comprise administering an IL33 protein to a subject. In some embodiments the subjects have cancer. In some embodiments the subjects have a chronic inflammatory condition. In some embodiments the present invention provides methods for treating cancer. In some embodiments the present invention provides methods for treating chronic inflammatory conditions.
Inventors:
BALACHANDRAN VINOD (US)
MERGHOUB TAHA (US)
MERGHOUB TAHA (US)
Application Number:
PCT/US2022/079278
Publication Date:
June 15, 2023
Filing Date:
November 04, 2022
Export Citation:
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER (US)
International Classes:
A61K38/20; A61P29/00; A61P35/00
Domestic Patent References:
| WO2021003138A1 | 2021-01-07 |
Foreign References:
| US20150259645A1 | 2015-09-17 | |||
| US20210299254A1 | 2021-09-30 |
Other References:
NERVIANI ET AL.: "Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer", J LEUKOC BIOL, vol. 104, 27 June 2018 (2018-06-27), pages 333 - 341, XP055675586, DOI: 10.1002/JLB.3MR0218-062R
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