Title:
IMAGING ANALYSIS METHOD AND DEVICE USING ION MOBILITY MASS SPECTROMETRY
Document Type and Number:
WIPO Patent Application WO/2024/018607
Kind Code:
A1
Abstract:
An embodiment of an imaging analysis device according to the present invention comprises: a measurement unit that acquires analysis result data by performing ion mobility mass spectrometry for each micro-region in a predetermined measurement region of a sample; a correlation investigation unit (22, 23) that investigates a correlation between m/z and ion mobility in the analysis result data acquired by the measurement unit on the basis of said data; and a data reduction unit (24, 25) that reduces the amount of the analysis result data by limiting an ion mobility range according to m/z or limiting an m/z range according to ion mobility, on the basis of the correlation result acquired by the correlation investigation unit.
Inventors:
YAMAGUCHI SHINICHI (JP)
Application Number:
PCT/JP2022/028407
Publication Date:
January 25, 2024
Filing Date:
July 21, 2022
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/623
Foreign References:
| US20210335588A1 | 2021-10-28 |
Other References:
MICHAL KLIMAN; JODY C. MAY; JOHN A. MCLEAN;: "Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR AND CELL BIOLOGY OF LIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1811, no. 11, 23 May 2011 (2011-05-23), AMSTERDAM, NL , pages 935 - 945, XP028330053, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2011.05.016
STAUBER, J. ; MACALEESE, L. ; FRANCK, J. ; CLAUDE, E. ; SNEL, M. ; KALETAS, B.K. ; WIEL, I.M.V.D. ; WISZTORSKI, M. ; FOURNIER, I. : "On-Tissue Protein Identification and Imaging by MALDI-Ion Mobility Mass Spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US, vol. 21, no. 3, 1 March 2010 (2010-03-01), US , pages 338 - 347, XP026917614, ISSN: 1044-0305, DOI: 10.1016/j.jasms.2009.09.016
MCCANN ANDRÉA; KUNE CHRISTOPHER; LA ROCCA RAPHAEL; OETJEN JANINA; ARIAS ANTHONY ARGUELLES; ONGENA MARC; FAR JOHANN; EPPE GAUTHIER;: "Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, AMSTERDAM, NL, vol. 39, 20 August 2021 (2021-08-20), AMSTERDAM, NL , pages 81 - 88, XP086898550, ISSN: 1740-6749, DOI: 10.1016/j.ddtec.2021.08.003
ALELYUNAS YUN WANG, KERRI SMITH, GARETH CLELAND, RUSSELL MORTISHIRE-SMITH, AND MARK D. WRONA: "Building a Collision Cross Section Library of Pharmaceutical Drugs Using the Vion IMS QTof Platform: Verification of System Performance, Precision and Deviation of CCS Measurements", WATERS [APPLICATION NOTE], 1 January 2017 (2017-01-01), pages 1 - 9, XP093130620, Retrieved from the Internet
STAUBER, J. ; MACALEESE, L. ; FRANCK, J. ; CLAUDE, E. ; SNEL, M. ; KALETAS, B.K. ; WIEL, I.M.V.D. ; WISZTORSKI, M. ; FOURNIER, I. : "On-Tissue Protein Identification and Imaging by MALDI-Ion Mobility Mass Spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US, vol. 21, no. 3, 1 March 2010 (2010-03-01), US , pages 338 - 347, XP026917614, ISSN: 1044-0305, DOI: 10.1016/j.jasms.2009.09.016
MCCANN ANDRÉA; KUNE CHRISTOPHER; LA ROCCA RAPHAEL; OETJEN JANINA; ARIAS ANTHONY ARGUELLES; ONGENA MARC; FAR JOHANN; EPPE GAUTHIER;: "Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, AMSTERDAM, NL, vol. 39, 20 August 2021 (2021-08-20), AMSTERDAM, NL , pages 81 - 88, XP086898550, ISSN: 1740-6749, DOI: 10.1016/j.ddtec.2021.08.003
ALELYUNAS YUN WANG, KERRI SMITH, GARETH CLELAND, RUSSELL MORTISHIRE-SMITH, AND MARK D. WRONA: "Building a Collision Cross Section Library of Pharmaceutical Drugs Using the Vion IMS QTof Platform: Verification of System Performance, Precision and Deviation of CCS Measurements", WATERS [APPLICATION NOTE], 1 January 2017 (2017-01-01), pages 1 - 9, XP093130620, Retrieved from the Internet
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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