Title:
IMAGING AND RADIOTHERAPY METHODS
Document Type and Number:
WIPO Patent Application WO/2010/048144
Kind Code:
A3
Abstract:
The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH ) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
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Inventors:
CUTHBERTSON ALAN (NO)
IVESON PETER BRIAN (GB)
BHALLA RAJIV (GB)
KUNIYIL KULANGARA VIJAYA RAJ (IN)
IVESON PETER BRIAN (GB)
BHALLA RAJIV (GB)
KUNIYIL KULANGARA VIJAYA RAJ (IN)
Application Number:
PCT/US2009/061271
Publication Date:
July 22, 2010
Filing Date:
October 20, 2009
Export Citation:
Assignee:
GE HEALTHCARE LTD (GB)
GEN ELECTRIC (US)
CUTHBERTSON ALAN (NO)
IVESON PETER BRIAN (GB)
BHALLA RAJIV (GB)
KUNIYIL KULANGARA VIJAYA RAJ (IN)
GEN ELECTRIC (US)
CUTHBERTSON ALAN (NO)
IVESON PETER BRIAN (GB)
BHALLA RAJIV (GB)
KUNIYIL KULANGARA VIJAYA RAJ (IN)
International Classes:
A61K51/04
Domestic Patent References:
| WO2003093498A1 | 2003-11-13 | |||
| WO2004080492A1 | 2004-09-23 | |||
| WO1996036344A1 | 1996-11-21 |
Other References:
MÄDING P. ET AL.: "18F-labelling of a potent nonpeptide CCR+ antagonist: synthesis of 1-(5-chloro2-{2-[(2R)-4-(4-[18F]fluorobenzyl2-methylpiperazin-1-yl]-2-oxoethoxy}phenyl)urain an automated module", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 49, 1 January 2006 (2006-01-01), pages 253 - 262, XP002581895
G. VAIDYANATHAN: "Targeting aldehyde dehydrogenase: a potential approach for cell labeling", NUCLEAR MEDICINE AND BIOLOGY, vol. 36, 8 November 2009 (2009-11-08), pages 919 - 929, XP002581896
GINESTIER CHRISTOPHE ET AL: "ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome", CELL STEM CELL, CELL PRESS, US LNKD- DOI:10.1016/J.STEM.2007.08.014, vol. 1, no. 5, 1 November 2007 (2007-11-01), pages 555 - 567, XP002529035, ISSN: 1934-5909
G. VAIDYANATHAN: "Targeting aldehyde dehydrogenase: a potential approach for cell labeling", NUCLEAR MEDICINE AND BIOLOGY, vol. 36, 8 November 2009 (2009-11-08), pages 919 - 929, XP002581896
GINESTIER CHRISTOPHE ET AL: "ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome", CELL STEM CELL, CELL PRESS, US LNKD- DOI:10.1016/J.STEM.2007.08.014, vol. 1, no. 5, 1 November 2007 (2007-11-01), pages 555 - 567, XP002529035, ISSN: 1934-5909
Attorney, Agent or Firm:
LEE, Christine et al. (Inc.101 Carnegie Cente, Princeton New Jersey, US)
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