IMAGING SAMPLE FOR MASS SPECTROMETER AND METHOD FOR PRODUCING SAME

WIPO Patent Application WO/2020/261651

A1

Provided are: a biological tissue thin slice sample for imaging which is prepared for a mass spectrometer which can eliminate physical and chemical influences and can adhesively support a thin frozen slice of a hard tissue or a large biological tissue even at low temperatures; and a method for producing the sample. The present invention relates to a biological tissue thin slice sample having a biological tissue adhering to a conductive adhesive film. The electrical resistance value between two points spaced apart by 75 mm or more on the surface of the conductive adhesive film to which the biological tissue adheres is 1.0×10-2Ω or more and less than 2.0×107Ω, and the median value of a glass transition temperature range of an adhesive of the conductive adhesive film determined by DSC measurement is -150°C to -40°C. The present invention also relates to a method for producing the sample.

YAMAMOTO TOYOHIKO (JP)

PCT/JP2020/008764

December 30, 2020

March 02, 2020

Click for automatic bibliography generation  

ASAHI CHEMICAL IND (JP)

G01N27/62; G01N1/28

JP2004037434A	2004-02-05
JP2003240755A	2003-08-27

SAIGUSA ET AL.: "Conductive Adhesive Film Expands the Utility of Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging", ANALYTICAL CHEMISTRY, vol. 91, no. 14, 18 June 2019 (2019-06-18), pages 8979 - 8986, XP055778184
"Histochemistry and Cytochemistry", 2005, JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY, pages: 95 - 107
BIOINTERPHASES, vol. 13, no. 3, May 2018 (2018-05-01), pages 03B414 - 1,03B414-7
See also references of EP 3992624A4

AOKI, Atsushi et al. (JP)

View/Download PDF      PDF Help

Previous Patent: RADIONUCLIDE PRODUCTION METHOD AND RADIONUCLIDE PRODUCTION SYSTEM

Next Patent: WORM SHAFT, WORM REDUCTION GEAR, AND METHOD FOR MANUFACTURING WORM SHAFT