IMIDAZO ISOINDOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Title:

IMIDAZO ISOINDOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/169421

Kind Code:

A1

Abstract:

The present invention relates to an imidazo isoindole derivative, a preparation method therefor and a medical use thereof. In particular, the present invention relates to the imidazo isoindole derivative as shown in the formula (I), a preparation method and pharmaceutical composition containing the derivative, and a use thereof for treating diseases with the pathological characteristic of IDO-mediated tryptophan metabolic pathways. The diseases comprise cancers, Alzheimer's disease, autoimmune diseases, depression, anxiety disorders, cataracts, psychological disorders and AIDS, wherein the substituents in the formula (I) are the same as those defined in the description.

Inventors:

TU WANGYANG (CN)
XU GUOJI (CN)
ZHANG HAITANG (CN)
CHI JIANGTAO (CN)
DONG QING (CN)

Application Number:

PCT/CN2016/079054

Publication Date:

October 27, 2016

Filing Date:

April 12, 2016

Export Citation:

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Assignee:

JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D487/04; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61P19/00; A61P25/24; A61P25/28; A61P35/00; A61P35/02; A61P37/06

Domestic Patent References:

WO2012142237A1

2012-10-18

Other References: