Title:
IMIDAZO[1,2-α ]PYRIDINYL BISPHOSPHONATES
Document Type and Number:
WIPO Patent Application WO/2010/033978
Kind Code:
A3
Abstract:
Novel imidazo[1,2-α]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.
Inventors:
EBETINO FRANK HALLOCK (US)
MAZUR ADAM (US)
LUNDY MARK WALDEN (US)
RUSSELL ROBERT GRAHAM GOODWIN (GB)
MAZUR ADAM (US)
LUNDY MARK WALDEN (US)
RUSSELL ROBERT GRAHAM GOODWIN (GB)
Application Number:
PCT/US2009/057817
Publication Date:
July 01, 2010
Filing Date:
September 22, 2009
Export Citation:
Assignee:
ISIS INNOVATION (GB)
EBETINO FRANK HALLOCK (US)
MAZUR ADAM (US)
LUNDY MARK WALDEN (US)
RUSSELL ROBERT GRAHAM GOODWIN (GB)
EBETINO FRANK HALLOCK (US)
MAZUR ADAM (US)
LUNDY MARK WALDEN (US)
RUSSELL ROBERT GRAHAM GOODWIN (GB)
International Classes:
C07D471/04; A61K31/435; A61K31/675; A61P29/00; A61P35/00; C07D471/02
Foreign References:
| US4990503A | 1991-02-05 |
Other References:
SZABO, C. ET AL.: "An investigation of bone resorption and Dictyostelium discoideum Growth Inhibition by Bisphosphonate Drugs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 14, 2002, pages 2894 - 2903, XP002293541
FULFARO, F. ET AL.: "The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials", PAIN., vol. 78, 1998, pages 157 - 169, XP001037953
SANDERS, J. M. ET AL.: "3-D QSAR investigations of the inhibition of Leishmanina major Farnesyl Pyrophophate Synthesis by Bisphosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 24, 2003, pages 5171 - 5183, XP009064956
LECERCLE, D ET AL.: "Phosphine-catalyzed alpha-P-addition on activated alkynes: new route to P-C-P backbones", ORGANIC LETTERS., vol. 8, no. 19, 2006, pages 4283 - 4285, XP008146984
See also references of EP 2350076A4
FULFARO, F. ET AL.: "The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials", PAIN., vol. 78, 1998, pages 157 - 169, XP001037953
SANDERS, J. M. ET AL.: "3-D QSAR investigations of the inhibition of Leishmanina major Farnesyl Pyrophophate Synthesis by Bisphosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 24, 2003, pages 5171 - 5183, XP009064956
LECERCLE, D ET AL.: "Phosphine-catalyzed alpha-P-addition on activated alkynes: new route to P-C-P backbones", ORGANIC LETTERS., vol. 8, no. 19, 2006, pages 4283 - 4285, XP008146984
See also references of EP 2350076A4
Attorney, Agent or Firm:
DEVEAU, Todd (Kayden Horstemeyer & Risley, LLP,600 Galleria Parkway,Suite 150, Atlanta GA, US)
Download PDF: