Title:
IMIDAZOL-4-ONE AND IMIDAZOLE-4-THIONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2010/062686
Kind Code:
A3
Abstract:
Imidazol-4-one or imidazole-4-thione compounds of formula (I) shown in the specification. Also disclosed is a method for treating a cannabinoid receptor-mediated disorder with these compounds.
Inventors:
SHIA KAK-SHAN
WU CHIEN-HUANG
YEH TENG-KUANG (US)
CHAO YU-SHENG (US)
WU CHIEN-HUANG
YEH TENG-KUANG (US)
CHAO YU-SHENG (US)
Application Number:
PCT/US2009/062771
Publication Date:
September 16, 2010
Filing Date:
October 30, 2009
Export Citation:
Assignee:
NAT HEALTH RESEARCH INSTITUTES
SHIA KAK-SHAN
WU CHIEN-HUANG
YEH TENG-KUANG (US)
CHAO YU-SHENG (US)
SHIA KAK-SHAN
WU CHIEN-HUANG
YEH TENG-KUANG (US)
CHAO YU-SHENG (US)
International Classes:
C07D403/04; A61K31/4155; A61P35/00; C07D233/61; C07D233/90; C07D403/02
Domestic Patent References:
| WO2007124854A1 | 2007-11-08 |
Foreign References:
| JPH0253787A | 1990-02-22 |
Other References:
CHIEN-HUANG WU ET AL.: "Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, 16 June 2009 (2009-06-16), pages 4496 - 4510
DONG JU JEO N ET AL.: "the Synthesis of a New Pyrazolylimidazolinone via 1,3-Dipolar Cycloaddition Reaction of N-Methyl Sydnone with Methyl Propiolate", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 19, no. 7, 21 March 1998 (1998-03-21), pages 725 - 726
DONG JU JEO N ET AL.: "the Synthesis of a New Pyrazolylimidazolinone via 1,3-Dipolar Cycloaddition Reaction of N-Methyl Sydnone with Methyl Propiolate", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 19, no. 7, 21 March 1998 (1998-03-21), pages 725 - 726
Attorney, Agent or Firm:
TSAO, Y. Rocky (10 Fawcett StreetCambridge, Massachusetts, US)
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