IMIDAZOL-5-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHODS AND USE THERROF

Title:

IMIDAZOL-5-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHODS AND USE THERROF

Document Type and Number:

WIPO Patent Application WO/2007/095789

Kind Code:

A1

Abstract:

The present application discloses a kind of imidazol-5-carboxylic acid derivatives, and preparation methods thereof. The said derivatives are angiotensin II antagonists, which show strongly antagonist activity against angiotensin II, and high antihypertensive activity. So they can be used as therapeutical agents against hypertension.

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Inventors:

GUO JIANHUI (CN)
AN DONG (CN)

Application Number:

PCT/CN2006/001914

Publication Date:

August 30, 2007

Filing Date:

July 31, 2006

Export Citation:

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Assignee:

SHANGHAI ALLIST PHARMACEUTICAL (CN)
GUO JIANHUI (CN)
AN DONG (CN)

International Classes:

C07D403/10; A61K31/41; A61K31/4164; A61P9/12; C07D233/68; C07D233/90; C07D405/10

Domestic Patent References:

WO2005011646A2	2005-02-10
WO2005023182A2	2005-03-17

Foreign References:

US5616599A	1997-04-01
CN1071426A	1993-04-28
EP0253310A2	1988-01-20
US5196444A	1993-03-23
US5616599A	1997-04-01
US5298519A	1994-03-29

Other References:

MEALY N. ET AL.: "Elisartan potassium. Antihypertensive angiotensin II antagonist. HN-65021", DRUGS OF THE FUTURE, vol. 21, no. 2, 1996, pages 139 - 142, XP008108961
NAYLOR E.M. ET AL.: "POTENT IMIDAZOLE ANGIOTENSIN II ANTAGONISTS: ACYL SULFONAMIDES AND ACYL SULFAMIDES AS TETRAZOLE REPLACEMENTS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 1, pages 69 - 74, XP008110056
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 40, 1995, pages 591 - 593
See also references of EP 1988090A4

Attorney, Agent or Firm:

SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (435 Guiping Road, Shanghai 3, CN)

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