Title:
IMIDAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/102404
Kind Code:
A1
Abstract:
Disclosed are: a novel compound having an inhibitory activity on S1P lyase and capable of inducing the decrease in the number of lymphocytes or an isotope or pharmaceutically acceptable salt of the compound; and a pharmaceutical composition containing the compound or the isotope or pharmaceutically acceptable salt of the compound as an active ingredient. Specifically disclosed is a compound represented by general formula (I) or (II) or an isotope or pharmaceutically acceptable salt of the compound.
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Inventors:
MACHINAGA NOBUO
CHIBA JUN
MURO FUMIHITO
YUITA HIROSHI
WATANABE JUN
CHIBA JUN
MURO FUMIHITO
YUITA HIROSHI
WATANABE JUN
Application Number:
PCT/JP2011/053336
Publication Date:
August 25, 2011
Filing Date:
February 17, 2011
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MACHINAGA NOBUO
CHIBA JUN
MURO FUMIHITO
YUITA HIROSHI
WATANABE JUN
MACHINAGA NOBUO
CHIBA JUN
MURO FUMIHITO
YUITA HIROSHI
WATANABE JUN
International Classes:
C07D233/64; A61K31/4164; A61P1/04; A61P9/14; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/04; A61P19/02; A61P21/00; A61P25/00; A61P27/14; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D233/90; C07D405/04; C07D405/06
Domestic Patent References:
| WO1984003441A1 | 1984-09-13 | |||
| WO2007100617A2 | 2007-09-07 | |||
| WO2008128045A1 | 2008-10-23 | |||
| WO2008109314A1 | 2008-09-12 | |||
| WO1997046543A1 | 1997-12-11 |
Foreign References:
| JP2009527564A | 2009-07-30 | |||
| US20090318516A1 | 2009-12-24 |
Other References:
See also references of EP 2537831A4
SCIENCE, vol. 296, 2002, pages 346 - 349
SCIENCE, vol. 309, 2005, pages 1735 - 1739
XENOBIOTICA, vol. 40, no. 5, 2010, pages 350 - 356
J. MED. CHEM., vol. 52, 2009, pages 3941 - 3953
J. MED. CHEM., vol. 53, 2010, pages 8650 - 8662
POVL KROGSGAARD-LARSEN ET AL.: "A Text Book of Drug Design and Development", 1996, HARWOOD ACADEMIC PUBLISHERS, pages: 351 - 385
JOURNAL OF THE CHEMICAL SOCIETY, vol. 10, 1980, pages 2310 - 2315
T. H. GREENE; P. G. WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC
ORGANIC LETTERS, vol. 4, 2002, pages 4133 - 4134
"Experimental Chemistry", vol. 26, MARUZEN PUBLISHING, article "Organic Synthesis III: asymmetric synthesis/reduction/sugar/labeled compound", pages: 185 - 245
TETRAHEDRON LETTERS, vol. 48, 2006, pages 377 - 380
ORG. LETT., vol. 4, 2002, pages 4133
J. ORG. CHEM., vol. 69, 2004, pages 5934
FEBS LETTERS, vol. 350, 1994, pages 91 - 95
JBC, vol. 266, no. 19, 1991, pages 12502 - 12507
CLIN. EXP. IMMUNOL., vol. 120, 2000, pages 526 - 531
J. NEUROIMMUNOL., vol. 129, 2002, pages 1 - 9
ANNU. REV. IMMUNOL., vol. 10, 1992, pages 153 - 187
EUR. J. IMMUNOL., vol. 25, 1995, pages 1951 - 1959
CURRENT PROTOCOLS IN IMMUNOLOGY, 1996
ARTHRITIS RHEUM., vol. 62, no. 1, January 2010 (2010-01-01), pages 82 - 92
ARTHRITIS RES THER., vol. 10, no. 3, 5 June 2008 (2008-06-05), pages R66
J IMMUNOL., vol. 170, no. 8, 15 April 2003 (2003-04-15), pages 4318 - 24
J IMMUNOL., vol. 182, no. 9, 1 May 2009 (2009-05-01), pages 5836 - 45
J CLIN INVEST., vol. 118, no. 2, February 2008 (2008-02-01), pages 597 - 607
NATURE, vol. 445, 2007, pages 648 - 651
CURRENT PROTOCOLS IN IMMUNOLOGY, 2001, pages 15.19.1 - 15.19.14
PROC NAT1 ACAD SCI U S A., vol. 106, no. 9, 6 February 2009 (2009-02-06), pages 3300 - 5
CURRENT PROTOCOLS IN IMMUNOLOGY, 2002, pages 15.20.1 - 15.20.22
AM. J. RESPIR. CELL MOL. BIOL., 10 December 2010 (2010-12-10)
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 97, no. 2, 2008, pages 712 - 725
SCIENCE, vol. 296, 2002, pages 346 - 349
SCIENCE, vol. 309, 2005, pages 1735 - 1739
XENOBIOTICA, vol. 40, no. 5, 2010, pages 350 - 356
J. MED. CHEM., vol. 52, 2009, pages 3941 - 3953
J. MED. CHEM., vol. 53, 2010, pages 8650 - 8662
POVL KROGSGAARD-LARSEN ET AL.: "A Text Book of Drug Design and Development", 1996, HARWOOD ACADEMIC PUBLISHERS, pages: 351 - 385
JOURNAL OF THE CHEMICAL SOCIETY, vol. 10, 1980, pages 2310 - 2315
T. H. GREENE; P. G. WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC
ORGANIC LETTERS, vol. 4, 2002, pages 4133 - 4134
"Experimental Chemistry", vol. 26, MARUZEN PUBLISHING, article "Organic Synthesis III: asymmetric synthesis/reduction/sugar/labeled compound", pages: 185 - 245
TETRAHEDRON LETTERS, vol. 48, 2006, pages 377 - 380
ORG. LETT., vol. 4, 2002, pages 4133
J. ORG. CHEM., vol. 69, 2004, pages 5934
FEBS LETTERS, vol. 350, 1994, pages 91 - 95
JBC, vol. 266, no. 19, 1991, pages 12502 - 12507
CLIN. EXP. IMMUNOL., vol. 120, 2000, pages 526 - 531
J. NEUROIMMUNOL., vol. 129, 2002, pages 1 - 9
ANNU. REV. IMMUNOL., vol. 10, 1992, pages 153 - 187
EUR. J. IMMUNOL., vol. 25, 1995, pages 1951 - 1959
CURRENT PROTOCOLS IN IMMUNOLOGY, 1996
ARTHRITIS RHEUM., vol. 62, no. 1, January 2010 (2010-01-01), pages 82 - 92
ARTHRITIS RES THER., vol. 10, no. 3, 5 June 2008 (2008-06-05), pages R66
J IMMUNOL., vol. 170, no. 8, 15 April 2003 (2003-04-15), pages 4318 - 24
J IMMUNOL., vol. 182, no. 9, 1 May 2009 (2009-05-01), pages 5836 - 45
J CLIN INVEST., vol. 118, no. 2, February 2008 (2008-02-01), pages 597 - 607
NATURE, vol. 445, 2007, pages 648 - 651
CURRENT PROTOCOLS IN IMMUNOLOGY, 2001, pages 15.19.1 - 15.19.14
PROC NAT1 ACAD SCI U S A., vol. 106, no. 9, 6 February 2009 (2009-02-06), pages 3300 - 5
CURRENT PROTOCOLS IN IMMUNOLOGY, 2002, pages 15.20.1 - 15.20.22
AM. J. RESPIR. CELL MOL. BIOL., 10 December 2010 (2010-12-10)
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 97, no. 2, 2008, pages 712 - 725
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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