Title:
IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS
Document Type and Number:
WIPO Patent Application WO2002102375
Kind Code:
A3
Abstract:
The invention relates to compounds of general formula (I) where R = an alkyl, cycloalkylalkyl or aralkyl group optionally substituted on the aryl group; R<2> = a phenyl group, or R<2> = an optionally substituted biphenyl group and R<3> = H or alkyl and the pharmaceutically acceptable salts thereof. The above may be used for the production of a medicament for modulating sodium channels and in particular for treatment of pain (for example, neuropathic pain), epilepsy, neurodegenerative conditions and bipolar conditions.
Inventors:
BIGG DENNIS (FR)
POMMIER JACQUES (FR)
LIBERATORE ANNE-MARIE (FR)
POMMIER JACQUES (FR)
LIBERATORE ANNE-MARIE (FR)
Application Number:
PCT/FR2002/002039
Publication Date:
September 25, 2003
Filing Date:
June 14, 2002
Export Citation:
Assignee:
SOD CONSEILS RECH APPLIC (FR)
BIGG DENNIS (FR)
POMMIER JACQUES (FR)
LIBERATORE ANNE-MARIE (FR)
BIGG DENNIS (FR)
POMMIER JACQUES (FR)
LIBERATORE ANNE-MARIE (FR)
International Classes:
A61K31/00; C07D233/06; A61K31/415; A61K31/4164; A61K31/4174; A61P1/12; A61P9/06; A61P25/04; A61P25/08; A61P25/24; A61P25/28; C07D233/10; C07D233/54; (IPC1-7): A61K31/415
Domestic Patent References:
| WO2000071120A1 | 2000-11-30 | |||
| WO2001026656A2 | 2001-04-19 | |||
| WO2000057877A1 | 2000-10-05 | |||
| WO2001044201A1 | 2001-06-21 |
Other References:
SUENAGA, K. ET AL: "Catharsitoxins from the Chinese remedy qiung laug", TETRAHEDRON LETTERS (2001), 42(40), 7079-7081, XP004317896
LIPSHUTZ, BRUCE H. ET AL: "Protection of imidazoles as their [.beta.-(trimethylsilyl)ethoxy]methyl (SEM) derivatives", TETRAHEDRON LETT. (1986), 27(35), 4095-8, XP001053736
HEERDING, D. A. ET AL: "1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001), 11(16), 2061-2065, XP001059006
VENKATARAMAN, B. V. ET AL: "Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL. (1991), 344(4), 454-63, XP001061258
LIPSHUTZ, BRUCE H. ET AL: "Protection of imidazoles as their [.beta.-(trimethylsilyl)ethoxy]methyl (SEM) derivatives", TETRAHEDRON LETT. (1986), 27(35), 4095-8, XP001053736
HEERDING, D. A. ET AL: "1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001), 11(16), 2061-2065, XP001059006
VENKATARAMAN, B. V. ET AL: "Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL. (1991), 344(4), 454-63, XP001061258
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