Title:
IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/046555
Kind Code:
A1
Abstract:
Substituted imidazolylquinoxalinedione derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof and medicinal compositions comprising these compounds or salts thereof and pharmaceutically acceptable carriers and being useful as glutamate receptor antagonists, etc.. In said formula, wherein each symbol has the following meaning: A: (CH2)m or Ph-(CH2)p (Ph being phenyl); X: oxygen or NR4; R1: hydrogen, hydroxy or triazolyl, provided that X may be a bond when R1 is triazolyl; R2: hydrogen, nitro, halogenated lower alkyl, cyano, amino, mono- or di(lower alkyl)amino, or halogeno; R3 and R4: the same or different and each representing hydrogen or lower alkyl; n: 0, 1 or 2; m: an integer of 2 to 6; and p: an integer of 1 to 6.
Inventors:
SAKAMOTO SHUICHI (JP)
OHMORI JUNYA (JP)
SHISHIKURA JUN-ICHI (JP)
OKADA MASAMICHI (JP)
SASAMATA MASAO (JP)
OHMORI JUNYA (JP)
SHISHIKURA JUN-ICHI (JP)
OKADA MASAMICHI (JP)
SASAMATA MASAO (JP)
Application Number:
PCT/JP1997/001905
Publication Date:
December 11, 1997
Filing Date:
June 05, 1997
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
SAKAMOTO SHUICHI (JP)
OHMORI JUNYA (JP)
SHISHIKURA JUN ICHI (JP)
OKADA MASAMICHI (JP)
SASAMATA MASAO (JP)
SAKAMOTO SHUICHI (JP)
OHMORI JUNYA (JP)
SHISHIKURA JUN ICHI (JP)
OKADA MASAMICHI (JP)
SASAMATA MASAO (JP)
International Classes:
C07D403/04; A61K31/495; C07D521/00; (IPC1-7): C07D403/04; A61K31/495; C07D403/12
Domestic Patent References:
| WO1994026737A1 | 1994-11-24 |
Foreign References:
| JPH07165756A | 1995-06-27 | |||
| JPH083160A | 1996-01-09 | |||
| JPH08291071A | 1996-11-05 |
Other References:
See also references of EP 0919554A4
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