Title:
IMIDAZOLINE-2-THIONE STRUCTURE-BASED PROBE FOR SELECTIVELY DETECTING HYPOCHLORITE
Document Type and Number:
WIPO Patent Application WO/2016/129806
Kind Code:
A3
Abstract:
The present invention relates to an imidazoline-2-thione structure-based probe for selectively detecting hypochlorite. A imidazoline-2-thione structure-based compound according to the present invention maintains a structure thereof even in the intracellular environment, selectively reacts with exogenous or endogenous hypochlorite (OCl-) to change a fluorescent or absorption spectrum, and thus can be favorably used for detecting hypochlorite (OCl-) in cells.
Inventors:
YOON JUYOUNG (KR)
XU QINGLING (KR)
KIM GYOUNGMI (KR)
XU QINGLING (KR)
KIM GYOUNGMI (KR)
Application Number:
PCT/KR2015/014311
Publication Date:
October 06, 2016
Filing Date:
December 28, 2015
Export Citation:
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUND (KR)
International Classes:
C07D487/04; C07D235/04; C07D241/36; G01N31/22
Foreign References:
| JP2002268171A | 2002-09-18 | |||
| KR101096654B1 | 2011-12-21 |
Other References:
MAHRAN. A. M. ET AL.: "Synthesis and Antiproliferative Activity of Novel Polynuclear Heterocyclic; Compounds Derived from 2,3-diaminophenazine", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 90, 16 December 2013 (2013-12-16), pages 568 - 576, XP029125939
MITRA, R. ET AL.: "Substitution-Modulated Anticancer Activity of Half-Sandwich Ruthenium(II) complexes with Heterocyclic Ancillary Ligands", EUR.J. INORG. CHEM., vol. 2014, no. 22, 24 June 2014 (2014-06-24), pages 3536 - 3546, XP055316282
XU, Q. ET AL.: "Development of Imidazolíne-2-Thiones Based Two-Phot on Fluorescence Probes for Imaging Hypochlorite Generation in a Co-Culture System", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 54, no. 16, 20 February 2015 (2015-02-20), pages 4890 - 4894
MITRA, R. ET AL.: "Substitution-Modulated Anticancer Activity of Half-Sandwich Ruthenium(II) complexes with Heterocyclic Ancillary Ligands", EUR.J. INORG. CHEM., vol. 2014, no. 22, 24 June 2014 (2014-06-24), pages 3536 - 3546, XP055316282
XU, Q. ET AL.: "Development of Imidazolíne-2-Thiones Based Two-Phot on Fluorescence Probes for Imaging Hypochlorite Generation in a Co-Culture System", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 54, no. 16, 20 February 2015 (2015-02-20), pages 4890 - 4894
Attorney, Agent or Firm:
LEE, Won Hee (Sung-ji Heights II147, Teheran-ro, Gangnam-gu, Seoul, KR)
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