Title:
IMIDAZOLYLBENZENE COMPOUND AND USE THEREOF AS MEDICINE
Document Type and Number:
WIPO Patent Application WO/1994/018172
Kind Code:
A1
Abstract:
An imidazolylbenzene compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, having a glutamate-induced cranial nerve cell death inhibitor activity and being useful as an NMDA antagonist and a cranial nerve cell death inhibitor, wherein R1, R2 and R3 represent each hydrogen, halogen, nitro, cyano, amino, alkyl, acyl, phenyl or alkoxy; R4 represents hydrogen, alkyl or cycloalkyl; z represents -CH2-, -CH(OH)- or -CO-; the ring (a) represents piperidino or 1-piperazinyl; A represents hydrogen, hydroxy or alkyl; and B represents cycloalkyl, cycloalkylalkyl, acyl, aryl, aralkyl, heteroaryl or heteroarylalkyl.
Inventors:
MISHINA TADASHI (JP)
NISHIYAMA AKIRA (JP)
TSURUDA MINEO (JP)
NOGUCHI YUTAKA (JP)
KISHIMOTO TOSHIMITSU (JP)
NISHIYAMA AKIRA (JP)
TSURUDA MINEO (JP)
NOGUCHI YUTAKA (JP)
KISHIMOTO TOSHIMITSU (JP)
Application Number:
PCT/JP1994/000092
Publication Date:
August 18, 1994
Filing Date:
January 24, 1994
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
MISHINA TADASHI (JP)
NISHIYAMA AKIRA (JP)
TSURUDA MINEO (JP)
NOGUCHI YUTAKA (JP)
KISHIMOTO TOSHIMITSU (JP)
MISHINA TADASHI (JP)
NISHIYAMA AKIRA (JP)
TSURUDA MINEO (JP)
NOGUCHI YUTAKA (JP)
KISHIMOTO TOSHIMITSU (JP)
International Classes:
C07D233/61; C07D233/68; C07D233/70; C07D233/88; C07D233/90; C07D233/92; C07D401/10; C07D403/10; (IPC1-7): C07D233/61; A61K31/44; A61K31/445; A61K31/495; C07D233/68; C07D233/70; C07D233/88; C07D233/90; C07D233/92; C07D401/10; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14
Foreign References:
EP0306440A2 | 1989-03-08 | |||
JPS5976067A | 1984-04-28 | |||
JPS6463574A | 1989-03-09 |
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