Title:
IMIDAZOPYRIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/084312
Kind Code:
A1
Abstract:
[Problem] To provide a medicinal composition which functions to activate soluble guanylate cyclase (sGC) and which is for the treatment or prevention of various cardiovascular diseases that is based on an improvement in cGMP signals.
[Solution] An imidazo[1,2-a]pyridine compound represented by formula (I), which has a carbamoyl group at the 3-position of the imidazo[1,2-a]pyridine framework and has a specific ring group bonded to the 8-position through a methyleneoxy group, or a salt of the compound. The pyridine compound or salt functions to activate sGC and is useful as the active ingredient of a medicinal composition for the treatment or prevention of various cardiovascular diseases in which sGC participates, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension.
(In formula (I),
A1 is cyclohexyl, phenyl substituted by 1-3 fluorine atoms, or 3-fluoropyridin-2-yl and
R is a group represented by any of the formulae (i) to (vii).)
Inventors:
KUROSAKI TOSHIO (JP)
WATANABE TSUBASA (JP)
OHNE KAZUHIKO (JP)
ISHIOKA HIROKI (JP)
NOZAWA EISUKE (JP)
HANAZAWA TAKESHI (JP)
HACHIYA SHUNICHIRO (JP)
SHIBATA HIROSHI (JP)
KOGA YUJI (JP)
MIZOGUCHI RYO (JP)
WATANABE TSUBASA (JP)
OHNE KAZUHIKO (JP)
ISHIOKA HIROKI (JP)
NOZAWA EISUKE (JP)
HANAZAWA TAKESHI (JP)
HACHIYA SHUNICHIRO (JP)
SHIBATA HIROSHI (JP)
KOGA YUJI (JP)
MIZOGUCHI RYO (JP)
Application Number:
PCT/JP2013/082057
Publication Date:
June 05, 2014
Filing Date:
November 28, 2013
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/506; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P43/00
Domestic Patent References:
| WO2003076408A2 | 2003-09-18 | |||
| WO2000027394A1 | 2000-05-18 | |||
| WO1999063940A2 | 1999-12-16 | |||
| WO2011113606A1 | 2011-09-22 | |||
| WO2012165399A1 | 2012-12-06 | |||
| WO2000006569A1 | 2000-02-10 | |||
| WO2000021954A1 | 2000-04-20 | |||
| WO2001083490A1 | 2001-11-08 | |||
| WO2003004503A1 | 2003-01-16 | |||
| WO2003095451A1 | 2003-11-20 | |||
| WO2003086407A1 | 2003-10-23 | |||
| WO2003097063A1 | 2003-11-27 | |||
| WO2007124854A1 | 2007-11-08 | |||
| WO2007128454A1 | 2007-11-15 | |||
| WO2008031513A1 | 2008-03-20 | |||
| WO2008061657A1 | 2008-05-29 | |||
| WO2010078900A2 | 2010-07-15 | |||
| WO2010079120A1 | 2010-07-15 | |||
| WO2011147809A1 | 2011-12-01 | |||
| WO2012004258A1 | 2012-01-12 | |||
| WO2012004259A1 | 2012-01-12 | |||
| WO2012010576A1 | 2012-01-26 | |||
| WO2012010577A1 | 2012-01-26 | |||
| WO2012010578A1 | 2012-01-26 | |||
| WO2012028647A1 | 2012-03-08 | |||
| WO2012059548A1 | 2012-05-10 | |||
| WO2012059549A1 | 2012-05-10 | |||
| WO2012143510A1 | 2012-10-26 | |||
| WO2012152629A1 | 2012-11-15 | |||
| WO2012152630A1 | 2012-11-15 | |||
| WO2013004785A1 | 2013-01-10 | |||
| WO2013030288A1 | 2013-03-07 | |||
| WO2013104597A1 | 2013-07-18 | |||
| WO2013104598A2 | 2013-07-18 | |||
| WO2013104703A1 | 2013-07-18 | |||
| WO2003076408A2 | 2003-09-18 | |||
| WO2000027394A1 | 2000-05-18 | |||
| WO2001032604A1 | 2001-05-10 | |||
| WO1998037080A1 | 1998-08-27 | |||
| WO2001096335A1 | 2001-12-20 | |||
| WO2011113606A1 | 2011-09-22 | |||
| WO2012165399A1 | 2012-12-06 |
Foreign References:
| JP2003513064A | 2003-04-08 | |||
| JP2010503627A | 2010-02-04 | |||
| JP2001512477A | 2001-08-21 | |||
| JPH07242666A | 1995-09-19 | |||
| JPS63225376A | 1988-09-20 | |||
| JPH07242666A | 1995-09-19 |
Other References:
KAMINSKI, J.J. ET AL.: "Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a] pyridines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 7, 1985, pages 876 - 892, XP002094814
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 56, 2010, pages 229
BLOOD, vol. 84, 1994, pages 4226
JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, 1985, pages 876
EUR. J. VASE. ENDOVASC. SURG, vol. 33, no. 1, 2007, pages S1
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY
DRUG DESIGN, pages 163 - 198
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"Courses in Experimental Chemistry", vol. 16, 2005, MARUZEN
MITSUNOBU, O., SYNTHESIS, 1981, pages 1
TSUNODA, T. ET AL., TETRAHEDRON LETTERS, vol. 36, 1995, pages 2529
TETRAHEDRON LETTERS, vol. 37, 1996, pages 2463
"Courses in Experimental Chemistry", vol. 14, 2005, MARUZEN
J. ORG. CHEM., vol. 66, 2001, pages 8772 - 8778
CHEM. REV., vol. 94, no. 8, 1994, pages 2483
See also references of EP 2927231A4
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 56, 2010, pages 229
BLOOD, vol. 84, 1994, pages 4226
JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, 1985, pages 876
EUR. J. VASE. ENDOVASC. SURG, vol. 33, no. 1, 2007, pages S1
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY
DRUG DESIGN, pages 163 - 198
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"Courses in Experimental Chemistry", vol. 16, 2005, MARUZEN
MITSUNOBU, O., SYNTHESIS, 1981, pages 1
TSUNODA, T. ET AL., TETRAHEDRON LETTERS, vol. 36, 1995, pages 2529
TETRAHEDRON LETTERS, vol. 37, 1996, pages 2463
"Courses in Experimental Chemistry", vol. 14, 2005, MARUZEN
J. ORG. CHEM., vol. 66, 2001, pages 8772 - 8778
CHEM. REV., vol. 94, no. 8, 1994, pages 2483
See also references of EP 2927231A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
Download PDF: