IMIDAZOYLALKYL SUBSTITUTED WITH A FIVE, SIX OR SEVEN MEMBERED HETEROCYCLIC RING CONTAINING ONE NITROGEN ATOM

Title:

IMIDAZOYLALKYL SUBSTITUTED WITH A FIVE, SIX OR SEVEN MEMBERED HETEROCYCLIC RING CONTAINING ONE NITROGEN ATOM

Document Type and Number:

WIPO Patent Application WO1999024421

Kind Code:

A8

Abstract:

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula (I). Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma) i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, Schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula (I) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of Formula (I) in combination or admixture with a histamine H1 receptor antagonist.

Inventors:

VACCARO WAYNE D (US)
WOLIN RONALD L (US)
SOLOMON DANIEL M (US)
ASLANIAN ROBERT G (US)
PIWINSKI JOHN J (US)
ROSENBLUM STUART B (US)

Application Number:

PCT/US1998/023224

Publication Date:

August 26, 1999

Filing Date:

November 05, 1998

Export Citation:

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Assignee:

SCHERING CORP (US)
VACCARO WAYNE D (US)
WOLIN RONALD L (US)
SOLOMON DANIEL M (US)
ASLANIAN ROBERT G (US)
PIWINSKI JOHN J (US)
ROSENBLUM STUART B (US)

International Classes:

A61K31/4178; A61K31/4427; A61K31/445; A61K31/454; A61K31/495; A61P1/00; A61P3/04; A61P9/00; A61P9/02; A61P25/00; A61P25/06; A61P25/18; A61P25/20; A61P25/28; A61P27/06; A61P37/08; C07D401/06; C07D403/06; (IPC1-7): C07D401/06; C07D403/06; A61K31/445; A61K31/415

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