Title:
IMINE DERIVATIVE AND AMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/094805
Kind Code:
A1
Abstract:
A medicine having prostaglandin D2 (PGD2) production inhibitory activity and having as an active ingredient a substance selected from compounds represented by the general formula (I): A-Y-B &lcub wherein A and B each independently represents an optionally substituted, cyclic hydrocarbon or heterocyclic group; and Y represents -CH=N-, -N=CH-, -CONH-, or -NHCO-, provided that the compounds represented by the following formula (I-1) [wherein X represents the formula -N=C(R5)- (wherein the left-side bond is bonded to the benzene ring and the right-side bond is bonded to the nitrogen atom) or the formula -NH-CH(R5)- (wherein the left-side bond is bonded to the benzene ring and the right-side bond is bonded to the nitrogen atom); R1, R2, R3, and R4 each independently represents hydrogen, halogeno, or optionally substituted C1-6 alkyl or hydroxy; R5 represents an optionally substituted C1-6 alkyl or C6-10 aryl group; and R represents optionally substituted amino] are excluded&rcub , salts, hydrates, and solvates.
Inventors:
TANAKA RIKA (JP)
KITAGAWA HIROHISA (JP)
SASAKI MASAO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
TOKUYAMA RYUKOU (JP)
KITAGAWA HIROHISA (JP)
SASAKI MASAO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
TOKUYAMA RYUKOU (JP)
Application Number:
PCT/JP2005/006464
Publication Date:
October 13, 2005
Filing Date:
April 01, 2005
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
TANAKA RIKA (JP)
KITAGAWA HIROHISA (JP)
SASAKI MASAO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
TOKUYAMA RYUKOU (JP)
TANAKA RIKA (JP)
KITAGAWA HIROHISA (JP)
SASAKI MASAO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
TOKUYAMA RYUKOU (JP)
International Classes:
A61K31/137; A61K31/18; A61K31/192; A61K31/357; A61K31/36; A61K31/403; A61K31/404; A61K31/41; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4184; A61K31/422; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4439; A61K31/4453; A61K31/4709; A61K31/53; A61P11/06; A61P15/00; A61P25/00; A61P25/04; A61P25/28; A61P37/08; A61P43/00; C07C251/24; C07D209/30; C07D209/86; C07D213/74; C07D215/38; C07D231/20; C07D231/38; C07D233/64; C07D235/08; C07D251/44; C07D257/06; C07D277/20; C07D277/42; C07D295/12; C07D317/50; C07D319/18; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07D417/12; (IPC1-7): A61K31/137; A61K31/18; A61K31/192; A61K31/357; A61K31/36; A61K31/403; A61K31/404; A61K31/41; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4184; A61K31/422; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4439; A61K31/4453; A61K31/4709; A61K31/53; A61P11/06; A61P15/00; A61P25/00; A61P25/04; A61P25/28; A61P37/08; A61P43/00; C07C251/24; C07D209/30; C07D209/86; C07D213/74; C07D215/38; C07D231/20; C07D231/38; C07D233/64; C07D235/08; C07D251/44; C07D257/06; C07D277/20; C07D277/42; C07D295/12; C07D317/50; C07D319/18; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07D417/12
Domestic Patent References:
| WO2003103658A1 | 2003-12-18 | |||
| WO2002049632A1 | 2002-06-27 | |||
| WO2004031180A1 | 2004-04-15 |
Foreign References:
| JPH0580561A | 1993-04-02 | |||
| GB2310207A | 1997-08-20 | |||
| JP2004002248A | 2004-01-08 |
Other References:
DUFFY K. ET AL.: "Hydrazinonapthalene and aozonaphthalene htrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.", J.MED. CHEM., vol. 44, no. 22, October 2001 (2001-10-01), pages 3730 - 3745, XP002197261
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
Download PDF: