Title:
IMMUNE ADJUSTMENT COMPOUND, USE THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2015/039587
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula I, wherein R is a halogen element or a C1-C6 alkyl group. The compound has S1P1 receptor agonist activity and selective specificity and has obviously-shortened half-life in-vivo, and therefore the compound is a high-quality second-generation S1P1 receptor agonist. The present invention also provides a use of the compound in preparing medicine for treating diseases or symptoms mediated by an S1P1 receptor, a pharmaceutical composition comprising the compound, and uses of the compound and the pharmaceutical composition in treating diseases or symptoms mediated by the S1P1 receptor.
Inventors:
ZHENG WEI (US)
PAN WUBIN (CA)
YANG XIN (CN)
PAN WUBIN (CA)
YANG XIN (CN)
Application Number:
PCT/CN2014/086538
Publication Date:
March 26, 2015
Filing Date:
September 15, 2014
Export Citation:
Assignee:
SUZHOU CONNECT BIOPHARMACEUTICALS LTD (CN)
International Classes:
C07D413/10; A61K31/4245; A61P1/00; A61P1/04; A61P3/10; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/04; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06
Domestic Patent References:
| WO2003105771A2 | 2003-12-24 | |||
| WO2004035538A1 | 2004-04-29 |
Foreign References:
| CN103480171A | 2014-01-01 |
Other References:
BUDDE ET AL., JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, 2002, pages 1073 - 83
LI ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 20, 2005, pages 6169 - 6173
LI ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 20, 2005, pages 6169 - 6173
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
北京瑞恒信达知识产权代理事务所（普通合伙） (CN)
北京瑞恒信达知识产权代理事务所（普通合伙） (CN)
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